Hyperplasia of “pancreatic polypeptide”-cells in the pancreas of juvenile diabetics

Gepts, W; Mey, J. De; Marichal-Pipeleers, M

doi:10.1007/bf00996324

Cited by 57 publications

(20 citation statements)

References 26 publications

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“…Similar histology was described in a child who died from congenital rubella (Bunnell and Monif, 1972), and the virus may persist in human pancreas for months or years (Cooper et al, 1965). Gepts et al (1977), using new immunocytochemical methods, found that 3-cells could be identified in JOD of recent onset. In chronic JOD the atrophic islets are composed mainly of glucagon, and of somatostatin cells.…”

Section: -Cell Destruction and Autoimmunitysupporting

confidence: 58%

Juvenile diabetes mellitus: possibility of prevention.

Farquhar¹

1979

Archives of Disease in Childhood

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Section: -Cell Destruction and Autoimmunitysupporting

confidence: 58%

Juvenile diabetes mellitus: possibility of prevention.

Farquhar¹

1979

Archives of Disease in Childhood

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“…High plasma concentrations of PP have been reported in patients with endocrine pancreatic tumors [32], [33] as well as in diabetic patients [34], [35]. A recent study by Kahleova et al showed an association of decrease in PP secretion with improvement in beta-cell function after diet-induced weight loss in subjects with type 2 diabetes [36].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Pancreatic Polypeptide Cell Distribution in the Human Pancreas

et al. 2013

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The pancreatic islet is mainly composed of beta-, alpha- and delta-cells with small numbers of pancreatic polypeptide (PP) and epsilon cells. It is known that there is a region in the head of the pancreas that is rich in PP-cells. In the present study, we examined the distribution of PP-cells, and assessed the influence of the PP-cell rich region to quantify the total islet mass. Pancreatic tissues were collected from donors with no history of diabetes or pancreatic diseases (n = 12). A stereological approach with a computer-assisted large-scale analysis of whole pancreatic sections was applied to quantify the entire distribution of endocrine cells within a given section. The initial whole pancreas analysis showed that a PP-cell rich region was largely restricted to the uncinate process with a clear boundary. The distinct distribution of PP-cells includes irregularly shaped clusters composed solely of PP-cells. Furthermore, in the PP-cell rich region, beta- and alpha-cell mass is significantly reduced compared to surrounding PP-cell poor regions. The results suggest that the analysis of the head region should distinguish the PP-cell rich region, which is best examined separately. This study presents an important implication for the regional selection and interpretation of the results.

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“…In pancreatitis, the PP-cell population of the affected tissue increases, particularly in the proliferating ductal epithelium. Attempts to quantify the changes in the PP-cell population in patients with T1D and T2D have produced conflicting reports of increased (Gepts et al 1977) or unaltered (Clark et al 1988;Rahier et al 1983b;Stefan et al 1982b) numbers. Given the propensity for PP-rich islets in the head of the pancreas, these discrepancies may reflect differences in the tissue sampling procedures.…”

Section: Pancreatic Polypeptide-cells; the Role Of Pp In Diabetesmentioning

confidence: 99%

Alpha-, Delta- and PP-cells

Brereton

Vergari

Zhang

et al. 2015

J Histochem Cytochem.

162

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SummaryIslet non-β-cells, the α-δ-and pancreatic polypeptide cells (PP-cells), are important components of islet architecture and intercellular communication. In α-cells, glucagon is found in electron-dense granules; granule exocytosis is calciumdependent via P/Q-type Ca 2+ -channels, which may be clustered at designated cell membrane sites. Somatostatin-containing δ-cells are neuron-like, creating a network for intra-islet communication. Somatostatin 1-28 and 1-14 have a short bioactive half-life, suggesting inhibitory action via paracrine signaling. PP-cells are the most infrequent islet cell type. The embryologically separate ventral pancreas anlage contains PP-rich islets that are morphologically diffuse and α-cell deficient. Tissue samples taken from the head region are unlikely to be representative of the whole pancreas. PP has anorexic effects on gastro-intestinal function and alters insulin and glucagon secretion. Islet architecture is disrupted in rodent diabetic models, diabetic primates and human Type 1 and Type 2 diabetes, with an increased α-cell population and relocation of non-β-cells to central areas of the islet. In diabetes, the transdifferentiation of non-β-cells, with changes in hormone content, suggests plasticity of islet cells but cellular function may be compromised. Understanding how diabetes-related disordered islet structure influences intra-islet cellular communication could clarify how non-β-cells contribute to the control of islet function. (J Histochem Cytochem 63:575-591, 2015)

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Hyperplasia of “pancreatic polypeptide”-cells in the pancreas of juvenile diabetics

Cited by 57 publications

References 26 publications

Juvenile diabetes mellitus: possibility of prevention.

Juvenile diabetes mellitus: possibility of prevention.

Quantitative Analysis of Pancreatic Polypeptide Cell Distribution in the Human Pancreas

Alpha-, Delta- and PP-cells

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