Both Neuropeptide Y and Serotonin Are Necessary for Entrainment of Circadian Rhythms in Mice by Daily Treadmill Running Schedules

Marchant, Elliott G.; Watson, Neil V.; Mistlberger, Ralph E.

doi:10.1523/jneurosci.17-20-07974.1997

Cited by 146 publications

(109 citation statements)

References 70 publications

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“…The behavioral phase advance in calorie-restricted mice cannot be ascribed to a shortening of because no changes were detected before versus after food restriction, nor can it be explained by transient hyperactivity it produces, although such bouts of activity during the subjective day can induce phase shifts of the SCN clock in nocturnal rodents (Mrosovsky et al, 1989;Van Reeth and Turek, 1989;Marchant et al, 1997). The food-anticipatory bout of activity that hypocalorie-fed rodents expressed before mealtime was initially considered to play a role in the behavioral phase advance.…”

Section: Discussionmentioning

confidence: 99%

“…Serotonergic inputs from raphe nuclei and NPYergic projections from intergeniculate leaflets are neuronal pathways that have been shown to convey nonphotic signals to the SCN (Marchant et al, 1997). These pathways and projections from the ventromedial hypothalamic nuclei may also participate in transmitting nonphotic cues associated with hypocaloric feeding signals to the SCN (Challet and Pevet, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

Mendoza¹,

Graff²,

Dardente³

et al. 2005

J. Neurosci.

190

173

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The suprachiasmatic nuclei (SCN) of the hypothalamus contain the master mammalian circadian clock, which is mainly reset by light. Temporal restricted feeding, a potent synchronizer of peripheral oscillators, has only weak influence on light-entrained rhythms via the SCN, unless restricted feeding is coupled with calorie restriction, thereby altering phase angle of photic synchronization. Effects of daytime restricted feeding were investigated on the mouse circadian system. Normocaloric feeding at midday led to a predominantly diurnal (60%) food intake and decreased blood glucose in the afternoon, but it did not affect the phase of locomotor activity rhythm or vasopressin expression in the SCN. In contrast, hypocaloric feeding at midday led to 2-4 h phase advances of three circadian outputs, locomotor activity rhythm, pineal melatonin, and vasopressin mRNA cycle in the SCN, and it decreased daily levels of blood glucose. Furthermore, Per1 and Cry2 oscillations in the SCN were phase advanced by 1 and 3 h, respectively, in hypocalorie-but not in normocalorie-fed mice. The phase of Per2 and Bmal1 expression remained unchanged regardless of feeding condition. Moreover, the shape of behavioral phase-response curve to light and light-induced expression of Per1 in the SCN were markedly modified in hypocalorie-fed mice compared with animals fed ad libitum. The present study shows that diurnal hypocaloric feeding affects not only the temporal organization of the SCN clockwork and circadian outputs in mice under light/dark cycle but also photic responses of the circadian system, thus indicating that energy metabolism modulates circadian rhythmicity and gating of photic inputs in mammals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

Mendoza¹,

Graff²,

Dardente³

et al. 2005

J. Neurosci.

190

173

View full text Add to dashboard Cite

show abstract

“…The evidence supporting the importance of the IGL and NPY in nonphotic shifting is clear (Challet et a/., 1996;Harrington, 1997;lvlarchant & Mistlberger, 1996;Marchant et a/., 1997;Maywood et a/,, 1997). Activation of the IGL is both necessary and sufficient to induce nonphotic resetting.…”

Section: Nonphotic Signallingmentioning

confidence: 98%

Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters

Landry

Mistlberger

2005

Brain Research

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“…Marchant et al (1997) (37) injured two neural structures (intergeniculate leaflet and rafe nuclei) in blind rats and tried to synchronize them through PE. The animals did not present synchronization of the activity / rest rhythm with exposition to PE cycles.…”

Section: Physical Exercise As a Non-photic Synchronizermentioning

confidence: 99%

Sincronização não-fótica: o efeito do exercício físico aeróbio

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Fortes

Santos

et al. 2007

Rev Bras Med Esporte

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The main alterations, either acute or chronic, caused by aerobic physical exercise (PE) over the body are generally well-known. However, there is a particular effect of PE which started to be elucidated in the beginning of the 90's in humans which has the capacity to alter the temporal relationship of the body with the environment. The modification of the expression of the circadian rhythms caused by PE qualifies it as a synchronizer of the biological oscillators. The main synchronizer of the biological rhythm is the light / dark geophysical cycle. The day / night rotation which occurs through differences in the luminosity levels is perceived through photic ways by the CTS. These stimuli, called photic, provide temporal information to the CTS synchronizing hence the biological oscillators to this environmental cycle. Other stimuli are also capable to synchronize them and are called non-photic synchronizers. This review writes about the effect of PE over the temporization system as well as discusses the possible and probable chronobiological applications of the mentioned knowledge. PE may affect the CTS through non-photic ways, being hence able to benefit health of individuals in several situations, such as transmeridian flights, night shift tasks and sleep disturbs. Moreover, we highlight that further studies should be conducted on individuals' routine in order to better understand the relationship between different synchronizers as well as their contribution in a real context.

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Both Neuropeptide Y and Serotonin Are Necessary for Entrainment of Circadian Rhythms in Mice by Daily Treadmill Running Schedules

Cited by 146 publications

References 70 publications

Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

Differential effects of constant light on circadian clock resetting by photic and nonphotic stimuli in Syrian hamsters

Sincronização não-fótica: o efeito do exercício físico aeróbio

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