Bone Grafting Enhanced by Platelet-Rich Plasma in Treatment of Avascular Necrosis of Femoral Head

Корыткин, А. А.; Зыкин, А А; Zakharova, D. V.; Новикова, Я С

doi:10.21823/2311-2905-2018-24-1-115-122

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Over a long period of clinical use, the possibilities of PRP have been widely studied in relation to fractures of long bones, ligamentous apparatus damage, tendinopathies, degenerative and nonspecific inflammatory diseases of the joints, fistulas and bedsores that do not heal for a long time, pathologies of intervertebral discs, stabilizing operations of the spine [33][34][35][36][37][38][39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

“…However, even in those medical fields where considerable experience has been gained: orthopedics and traumatology, sports medicine, combustiology, maxillofacial surgery, plastic surgery [33][34][35][36][37][38][39][40][41][42], today there are many unclear questions and there are no definite clinical protocols regarding the application of PRP.…”

Section: Introductionmentioning

confidence: 99%

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The Results of Autotransfusion With Platelet Rich Plasma in Spinal Neurosurgery

Pedachenko¹

2018

Ž. klìn. eksp. med. dosl.

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THE RESULTS OF AUTOTRANSFUSION WITH PLATELET RICH PLASMA IN SPINAL NEUROSURGERY. Introduction. Рlatelet-rich plasma (PRP), a blood plasma separated by centrifugation with highly abundant platelets, has multiple applications in many healthcare fields for the improvement of soft and bone tissues regeneration. The studies of PRP implementation results in spine neurosurgery are of high demand in case of pathologies related to the degeneration or injury of living bone and cartilaginous elements of vertebral column, which require the installation of vertebral interbody fusion system. Purpose. Improvement of surgical treatment outcomes by means of improving postoperative wound healing and reducing pain severity after the installation of transpedicular fixation systems in the lumbar spine using a biotechnological method which has a multimodal effect on regeneration processes and is simple and cost-effective Materials and Methods. The results of transpedicular stabilization in lumbar spine vertebral column were assessed within the early postoperational period in two groups of patients comparable in age and health status with spondylolisthesis and spinal motion segment instability. Patients from the main group (n = 20, average age 47.8 ± 6.6 years) received PRP during the operation as compared to the control one (n = 30, average age 46.9 ± 5.6 years) without PRP injections. Results. It was found that during the first day post-operation the pain severity in the main group was significantly reduced (1.6 ± 0.7 points according to the visual analogous scale) as compared to the control (3.8 ± 0.9 points). Moreover, these characteristics before the discharge of the patients were 0.3 ± 0.3 and 2.0 ± 0.4 points respectively. It is noteworthy that the swelling and wound edges hyperemia were remarkably reduced after the PRP use. Finally, no complications, side-effect or systemic consequences of PRP were observed. Conclusions. Therefore, the local injections of PRP during the installment of transpedicular stabilization system in lumbar spine is easyto-handle and safe approach favoring the quick recovery in early postoperational period.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Results of Autotransfusion With Platelet Rich Plasma in Spinal Neurosurgery

Pedachenko¹

2018

Ž. klìn. eksp. med. dosl.

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Platelet-rich plasma products in traumatology and orthopaedics: classification issues (literature review)

Котельников

Петрович²,

Dolgushkin

et al. 2020

Aspirantskiy Vestnik Povolzhiya

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In recent years, biological growth factors contained in platelet-rich plasma (PRP) obtained from the whole blood have been actively used to regenerate tissues of the musculoskeletal system. There are a lot of methods for preparing PRP, devices and modes for obtaining it, including ready-made services for use in traumatology and orthopedics. A number of well-known protocols miss important points and features of handling biological material, and fail to give clear characteristics of the resulting product. At the same time, there are a number of products that are completely opposite in composition, method, place of application and time of application, which the authors denote as PRP. In the domestic and foreign literature, several attempts have been made to characterize and classify the types of products containing plasma with platelets as a basis. In this article, we describe the existing systems used to classify PRP drugs, highlight their advantages and disadvantages. Of course, due to the active use of PRP in various fields of medicine, there remains a need for the standardized universal nomenclature for describing biological therapies, as well as for a comprehensive and reproducible classification system for products obtained from autologous blood.

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Osteonecrosis of the Femoral Head: Another Legacy of COVID-19?

Myasoedov,

Shubnyakov,

Sereda

et al. 2023

Traumatology and Orthopedics of Russia

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Background. Recovery from COVID-19 does not always proceed without complications, especially in patients who have suffered severe forms of the disease. Most researchers confirm a significant increase in the incidence of osteonecrosis of the femoral head (ONFH) after COVID-19. However, there is no clear opinion on the individual aspects of the development and course of the disease. This is an extremely important issue that allows us to identify the main risk groups for the development of post-COVID-19 osteonecrosis and, consequently, to perform the earliest possible screening of this complication. Aims of the study: 1) To evaluate the impact of the past COVID-19 on epidemiologic parameters and clinical course of osteonecrosis of the femoral head in patients; 2) to study the causes of its development. Methods. We have analyzed the data of medical histories of 674 patients diagnosed with osteonecrosis of the femoral head who sought medical care in 2018 and in 2022. Patients were divided into 4 groups according to the presumed causes of development of the disease. The first group enrolled 183 patients who underwent COVID-19 and received steroid therapy (ST). The second group included 78 patients who underwent COVID-19 without ST therapy. The third group consisted of 103 patients with ONFH that manifested in 2022 without COVID-19 in the previous medical history. The comparison group was made up of 310 patients who developed ONFH in 2018 before the appearance of the SARS-CoV-2 virus. Results. The sample of patients with COVID-19-associated osteonecrosis differed significantly from patients without COVID-19, in terms of gender, age, time of disease onset, extent of the femoral head damage, and disease progression rate (p0.001). The level of early ONFH diagnosis was extremely low, not differing from that in the pre-pandemic period. Conclusion. The COVID-19 pandemic has increased the incidence of ONFH, significantly modifying both its epidemiology and clinical picture. Nevertheless, the vigilance of practitioners remains extremely low, which affects the timely diagnosis of the disease.

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Bone Grafting Enhanced by Platelet-Rich Plasma in Treatment of Avascular Necrosis of Femoral Head

Cited by 4 publications

References 22 publications

The Results of Autotransfusion With Platelet Rich Plasma in Spinal Neurosurgery

The Results of Autotransfusion With Platelet Rich Plasma in Spinal Neurosurgery

Platelet-rich plasma products in traumatology and orthopaedics: classification issues (literature review)

Osteonecrosis of the Femoral Head: Another Legacy of COVID-19?

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