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The article focuses on the role of Samara State Medical University in the development of innovative capacity of the Samara region in the sphere of healthcare and medical education. Special attention is given to the multilevel innovative infrastructure of SSMU, which includes such unique departments as the Center for groundbreaking research “IT in medicine”, the scientific and production technology park, scientific-educational centers, small innovative enterprises and others. In particular, this infrastructure is an integrative platform not only for own innovation process at the university, but also for the development of current medical science prospects, for the formation of unique competences in interdisciplinary spheres, for the realization of science-based business, for the organization of innovative educational process (especially in the sphere of simulation technologies), for implementation into clinical practice, and also for successful incorporation into international cooperation.

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Pain in the lower back is one of the frequent reasons for seeking medical help among people over 60 years of age. The study of this problem is of interest to specialists of various profiles, including neurologists, rheumatologists, orthopedic surgeons and therapists. Purpose — to determine prevalence rate of sacroiliac joint pathology in elderly patients with low back pain (LBP) in conjunction with evaluation of clinical significance of bone resorption and cytokines markers. Materials and Methods.The study was conducted with consecutive inclusion of patients (n = 259) with mean age of 65.5 year old [62.5; 69.5] who addressed the hospital for the first time in calendar year with complaints for low back pain. The authors performed MRI examination of lumbar-sacral spine and sacroiliac joint, assessed transforming growth factor β1 (TGF β1), interleukin (IL) 1β and IL-6, Beta-Crosslaps (β-CrossLaps) criteria, P1NP (N-terminal propeptide of procollagen type I) concentration and deoxypyridinoline (DPD) level. Results. 39.4% of patients older 60 years with low back pain on MRI demonstrated changes in sacroiliac joints with statistically significant higher (p = 0.037) pain level as compared to patients without pathology of sacroiliac joint, as well as higher values of TGF-β1 (p = 0.033), IL-1β (p = 0.028), IL-6 (p = 0.041), β-CrossLaps (p = 0.028), P1NP (p = 0.037) and DPD (p = 0.002). Conclusion. Reported alterations in sacroiliac joint conditioned by degenerative and dystrophic processes are associated with distinctive signs of osteoarthrosis and confirm non-specific inflammation active with bone resorption in patients with low back pain.

The aim of the investigation was to evaluate the possibilities of applying 3D modeling and computer navigation in treatment of benign tumors and tumor-like diseases of tubular bones. Materials and Methods. The study involved 19 patients with benign tumors and tumor-like diseases of tubular bones of the skeleton, who were divided into two groups. The main group comprised 10 patients in whom three-dimensional models of affected bone segments were created in addition to radiography and computed tomography at the stage of preoperative planning. Surgical treatment was carried out using a navigation system. The control group included 9 patients who underwent only radiography and computed tomography of the affected segment at the stage of preoperative planning. Results. The use of 3D modeling in diagnosis and computer navigation in surgical treatment of benign tumors and tumor-like diseases of tubular bones helped to reduce the time of surgery from 121.5±11.3 to 81.1±9.7 min, intraoperative blood loss from 718.7±43.2 to 364.2±28.4 ml, pain intensity by visual analogue scale from 7.6±1.9 to 5.3±1.2 scores. These results were achieved through the development of intuitively simple for the operator system of real-time spatial orientation in the operating field, more accurate and measured surgical procedures, precise calculation of the required transplant volume, which minimized trauma to the donor area and contributed to reducing postoperative pain. Conclusion. The use of 3D modeling and computer navigation in treatment of patients with benign tumors and tumor-like diseases of tubular bones provides the possibility to improve immediate results of surgical treatment promoting fast social and functional adaptation of patients.

The study is devoted to the evaluation of the effectiveness of the new organizational model of medical rehabilitation in patients after the endoprosthetic hip replacement in conditions of the Samara State Medical University clinics.There were observed 348 patients underwent total endoprosthesis of the hip joint due to degenerative-dystrophic processes. In the comparison group consisted of 179 patients, the traditional approaches to re-rehabilitation remained. In the main group of 169 patients, a problem-oriented multidisciplinary approach was implemented, using the International Classification of Functioning (ICF) clinical scales to execute timely examination and route patients to medical organizations. Within the framework of the Pilot Project, for the patients of the main group there were worked out the stage-by-stage approach, continuity, consistency of received medical measures in specialized licensed medical rehabilitation clinics of the Ministry of Health of the Samara Region. There was executed the evaluation of immediate, remote results of clinical and functional parameters of patients after hip joint prosthetics within the framework of the Pilot Project. To evaluate the rehabilitation potential and prognosis, a clinical, laboratory, functional and biomechanical assessment of the patients’ condition was carried out based on radiography, rheovasography, electromyography, podography, thermography, psycho-logical testing, and scale analysis. The analysis of the effectiveness of the new organizational model of medical rehabilitation in patients after hip arthroplasty in conditions of Clinics of the Samara State Medical University is presented.

the effectiveness of new methods of the Achilles tendon reinforcement. Material and methods The experimental part of the work was performed in 3 stages using 60 biomannikins with intact Achilles tendon. A Krakow suture was used at stage 1 for a group of 20 tendons and a force that would result in rupture of the tendon was measured. Reinforcement was performed using the plantaris tendon (technical innovation offered at the Samara State Medical University) at the 2nd stage and the force required for the appearance of signs of rupture was subsequently measured. A portion of the peroneus longus tendon (RF patent No. 2616767) was used for reinforcement at the 3rd stage and the force measurement produced. Results The mean force required to rupture the Krakow suture applied to the tendon at the first stage was 11.5 kg., The force required to rupture the suture reinforced with the plantaris tendon at the second stage measured 33.4 kg. The force required to rupture the suture reinforced with a portion of the peroneus longus tendon at the third stage was 37.3 kg. Conclusion The new techniques offered to reinforce the Achilles tendon with the plantaris tendon and a portion of the peroneus longus tendon at the distal base facilitated increase in the strength of the injury site by 195.6 % and 214.4 %, respectively.