Blood Typing Profile of a School-Aged Population of a North Togo Township

Vovor, A.; Feteke, L; Kueviakoe, Irénée Messanh Delagnon; Kpatarou, Laye; Mawussi, Koffi; Magnang, Hézouwè; Segbena, A.

doi:10.3109/03630269.2014.963234

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…As shown by Segbena et al (2005) in Togo there is an incidence at birth of 1.17% of the homozygous form SS and the national average is 1.3% and there is an increase of HbS/HbC at the northern part of the country (Vovor et al, 2014).…”

Section: Introductionmentioning

confidence: 94%

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Dermane¹,

Kpegba²,

Metowogo³

et al. 2019

Int. J. Bio. Chem. Sci

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Sickle cell disease is a genetic disease very expanded all over the African block. In Togo like most African countries, it's one of major causes of morbidity and mortality. The available treatments are very ornamental and are most of the time remedy than cure. However, in our areas, the sicks use medicinal plants for treating themselves. It's in this scope that this study has been conducted in sight of assessing the anti-sickling activity of Newbouldia laevis extracts (leaves, roots and stem barks) based on Emmel test using 2% sodium metabisulphite. The extracts were also studied for its in vitro antioxidant activity using 2,2-diphenyl-1picrylhydrazyl (DPPH) and 2,2'-azobis (2-amidinopropane hydrochloride) (AAPH) methods. The results obtained show that the roots and the stem barks extracts have a comparable efficiency. These extracts enabled us to reduce the sickling rate respectively at 17% and 16% against 78% for the control that was incubated in the presence of 0.9% sodium chloride. The leaves extract led to hemolysis and hemolysing concentration was 5mg/ml. Light antioxidant activity in vitro was obtained for the two extracts. Our outcomes proved that in vitro, roots and stem barks of Newbouldia laevis extracts have an anti-sickling activity contrary to the hemolysing leaves extract.

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Section: Introductionmentioning

confidence: 94%

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Dermane¹,

Kpegba²,

Metowogo³

et al. 2019

Int. J. Bio. Chem. Sci

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“…There are more than 312,000 births of sickle cell children worldwide each year, with the vast majority of these births occurring in three countries: Nigeria, the Democratic Republic of Congo and India [4]. In Togo, a study was carried out by Vovor et al [5], on 570 children in the northern of the country and indicated a prevalence of 1.58% and 0%, respectively for Hb SC and Hb SS. Deaths caused by the complications of sickle cell disease are most often recorded in children under five, adolescents and pregnant women [6].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Sickling Activity of Extracts From the Stem and Roots Barks of Strychnos Innocua (Del.)

BRUKUM,

KPEGBA,

EVENAMEDE

et al. 2023

Int J Pharm Pharm Sci

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Objective: In Togo Strychnos innocua represents a plant traditionally used to cure sickle cell disease. This study aims to carry out a phytochemical study and evaluate the antioxidant and anti-sickling activity of Strychnos innocua root and stem barks to support its use. Methods: Hydroethanolic and ethanolic extracts of each plant organ were obtained by maceration. Polyphenol content was determined using the Folin-Ciocalteu’s reagent and the flavonoid content using Aluminium trichloride (AlCl3) method. The anti-sickling activity of hydroethanolic extracts of root and stem barks was tested on SS blood samples from sickle cell patients using the Emmel test. Antioxidant activity was assessed by DPPH and FRAP methods on both the hydroethanolic and ethanolic extracts. Results: Results indicate that the highest levels of polyphenols were measured in the hydroethanolic extract of the root barks (59.32±1.77 mg GAE/g) and the ethanol extract of the stem barks (98.27±2.44 mg GAE/g). The hydroethanolic extract of the root barks and the ethanolic extract of the stem barks showed high levels of flavonoids. Extracts from both organs significantly reduced falciformation (p<0.001) at a rate of 22% (root) and 35% (stem) compared with the control (94%). In addition, root and stem extracts showed slight antioxidant activity. Conclusion: Results justify the traditional use of Strychnos innocua roots in treating sickle cell anaemia.

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Systematic Literature Review Shows Gaps in Data on Global Prevalence and Birth Prevalence of Sickle Cell Disease and Sickle Cell Trait: Call for Action to Scale Up and Harmonize Data Collection

Colombatti,

Hegemann,

Medici

et al. 2023

JCM

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Sickle cell disease (SCD) is an inherited monogenic disorder with high prevalence throughout sub-Saharan Africa, the Mediterranean basin, the Middle East, and India. Sources of SCD epidemiology remain scarce and fragmented. A systematic literature review (SLR) to identify peer-reviewed studies on SCD epidemiology was performed, with a search of bibliographic databases and key conference proceedings from 1 January 2010 to 25 March 2022 (congress abstracts after 2018). The SLR followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Meta-analyses, using a binomial normal random-effects model, were performed to estimate global and regional prevalence and birth prevalence. Of 1770 journal articles and 468 abstracts screened, 115 publications met the inclusion criteria. Prevalence was highest in Africa (~800/100,000), followed by the Middle East (~200/100,000) and India (~100/100,000), in contrast to ~30/100,000 in Europe. Birth prevalence was highest in Africa (~1000/100,000) and lowest in North America (~50/100,000) and Europe (~30/100,000). This SLR confirmed that sub-Saharan and North-East Africa, India, the Middle East, and the Caribbean islands are global SCD hotspots. Publications including mortality data were sparse, and no conclusions could be drawn about mortality. The identified data were limited due to gaps in the published literature for large parts of the world population; the inconsistent reporting of SCD genotypes, diagnostic criteria, and settings; and a sparsity of peer-reviewed publications from countries with assumed high prevalence. This SLR demonstrated a lack of systematic knowledge and a need to provide uniform data collection on SCD prevalence and mortality.

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Blood Typing Profile of a School-Aged Population of a North Togo Township

Cited by 3 publications

References 7 publications

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Evaluation of the anti-sickling activity of <i>Newbouldia laevis</i> P. Beauv extracts

Antioxidant and Anti-Sickling Activity of Extracts From the Stem and Roots Barks of Strychnos Innocua (Del.)

Systematic Literature Review Shows Gaps in Data on Global Prevalence and Birth Prevalence of Sickle Cell Disease and Sickle Cell Trait: Call for Action to Scale Up and Harmonize Data Collection

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