Biparametric Potentiometric Analytical Microsystem Based on the Green Tape Technology

Abstract

The construction and evaluation of a Low Temperature Co-fired Ceramics (LTCC)-based microsystem prototype as a possible on-site microanalyzer to monitor the presence of two ions in water simultaneously is presented. The approach has been assayed to detect nitrate and chloride ions as model analytes by means of integrating in the same single substrate an ion selective polymeric membrane to nitrate and two screen-printed Ag/AgCl electrodes. One supplies the chloride ion concentration and the other is to complete the potentiometric detection system as the reference electrode. The results obtained by the full characterization of the microanalyzer prove the relevance of the proposal and the possibility to be transferred to real-world samples and environmental monitoring.

Microchannel conductivity measurements in microchip for on line monitoring of dephosphorylation rates of organic phosphates using paramagnetic-beads linked alkaline phosphatase

“…For this challenge, electrical transduction methods are more suitable for the detection of ionic species (oxidable or reducable) because of their high sensitivity and no need labelling step is required [4][5][6]. The relevance of electrochemical detection on microchips with improvement of micro nanoelectrode fabrication [7][8][9][10][11][12] has been widely proven, including the application of amperometric detection [13][14][15][16], and potentiometric [17][18][19]. However, contactless to the microelectrodes as electrical detection scheme with the electrolyte is the most promising [20][21][22][23].…”

Potentiometric analytical microsystem based on the integration of a gas-diffusion step for on-line ammonium determination in water recycling processes in manned space missions

“…This solution reaches the detector and finally it is carried to the waste outlet (w 3 ). An auxiliary 0.1 M KCl solution is continuously pumped at 0.1 mL min À1 through the fourth inlet port (a) and flows through the channel in which the reference electrode is placed in order to keep its potential at a constant value [26]. This channel merges with the main channel after the detection chamber, acting thus as a flowing liquid junction.…”

Molecular Microfluidic Bioanalysis: Recent Progress in Preconcentration, Separation, and Detection

“…Microfluidic systems with potentiometric detection have been developed and characterized. Among them, it can be mentioned the microanalyzer prototypes based on potentiometric measurements for various applications in analytical chemistry and biochemistry, such as ions detection [104], proteins [105], and Ph [106,107]. The achievement of receptors based on low temperature co-fired ceramic or LTCC for potentiometric microsystems (called μPOT) offers good electrical and mechanical properties, as well as reliability and stability measures.…”