Biosynthesis of copper nanoparticles using aqueous Tilia extract: antimicrobial and anticancer activities

Abstract

A cost-effective method for the biosynthesis of copper nanoparticles (Cu-NPLs) using Tilia extract under optimum conditions has been presented. The use of Tilia extracts for the synthesis of Cu-NPLs has been investigated for the first time. The Cu-NPLs are stable due to in situ bio-capping by the Tilia extract residues. Formation of metallic Cu was revealed by UV-vis and XRD analyses. UV-vis of Cu-NPLs showed an SPR characteristic peak at 563 nm (energy bandgap = 2.1 eV). Morphology and size of the as-prepared Cu-NPLs were determined using SEM and TEM studies. TEM observations show that the produced Cu-NPLs are hemispherical in shape with different diameters in the range 4.7–17.4 nm. The electrical conductivity of the Cu-NPLs was determined as 1.04 × 10−6 S cm-1 (at T = 120 K). The antimicrobial studies exhibited relatively high activity against pathogenic bacteria like Gram-positive & Gram-negative bacteria. Anticancer studies demonstrated the in vitro cytotoxicity value of Cu-NPLs against tested human colon cancer Caco-2 cells, human hepatic cancer HepG2 cells and human breast cancer Mcf-7 cells. To conclude, Cu-NPLs are promising in electronic devices and they possess a potential anticancer application for some human cancer therapy as well.

Green synthesis and characterization of copper nanoparticles using Piper retrofractum Vahl extract as bioreductor and capping agent

“…This result proves that CuNPs prepared using Piper retrofractum extract exhibited antibacterial activity. Similar findings were also reported in which CuNPs were synthesized using tilia extract [47] and cellulosic walnut shell material [48].…”

Green synthesis of copper & copper oxide nanoparticles using the extract of seedless dates

“…These peaks affirmed the adsorption of phenolic compounds from the seedless dates extract on the surface of the prepared nanoparticles via the interaction of π electrons [28]. Furthermore, the reduction of copper ions into copper nanoparticles was achieved under the effect of hydroxyl and carbonyl linkages in the extract's constituents [29]. In addition, since phenolic compounds were adsorbed on the surface of the nanoparticles, then the phenolic compounds may act as a capping agent, thus provide the nanoparticles with more stability.…”

Biosynthesis of Copper Oxide Nanoparticles by Marine Streptomyces MHM38 and their Preventive Efficacy Against Paracetamol-Inducing Hepatic Damage of Albino Rats

“…Such ndings are consistent with those of previous studies which examined Candidaalbicans and Pseudomonasaeruginosa antimicrobial activity of Cu-NPs. (Hassanien et al, 2018). The appearance of the inhibition area showed that in these locations there was no growth of bacteria.…”

“…The Cu-NPLs ' large surface area enhances their interaction with the microbes in order to perform wide antimicrobial operations (Shende et al, 2015). However, the few reports on Cu-NPLs antimicrobial research have shown that Cu-NPLs are effective against multiple pathogenic microorganisms (Hassanien et al, 2018). The anti-microbial activity of CuONPs was carried out on pathogenic bacterial strains Gram-positive bacteria (Enterococcus faecalis ATCC 29212), Gram-negative bacteria (Salmonella typhimurium ATCC 14028, Pseudomonas aeruginosa ATCC 9027, Escherichia coli ATCC 8939), fungi (Rhizoctonia solani, Fusarium solani, Aspergillus niger) and yeast (Candida albicans ATCC 10237) using the method of well diffusion, and the inhibition area values are shown in (Table 1 & gure 11).…”