“…Electrochemical aptasensors use an electrode surface to immobilize the aptamer and hold an electrochemical transducer to monitor the aptamer-target interaction, by detecting current or potential changes that occur at the transducer/bioreceptor interface/surface (Hong et al, 2012;Monošík et al, 2012;Sadik et al, 2009;Thévenot et al, 1999Thévenot et al, , 2001. The electrochemical transduction presents considerable advantages over optical, piezoelectric or thermal detection (Deng et al, 2013a;Radi, 2011), such as high sensitivity and selectivity, the ability to work with turbid samples, compatibility with novel microfabrication technologies, inherent miniaturization, disposability and accuracy, simplicity, robustness, possibility of usage for on-line control, fast response, and relatively low manufacturing cost; thus making electrochemical aptasensors extremely attractive for diagnostic and use in point-ofcare devices, in addition to simultaneous multi-analyte detection (Arshak et al, 2009;Radi, 2011;Saberian et al, 2011;Song et al, 2008;Velasco-Garcia and Missailidis, 2009;Velusamy et al, 2010;Xu et al, 2009).…”