“…Most of these studies were controlled, but five were of a simple before-after design [14,18,47,49]. Seven small studies (n = 12-44) focused on AD [14,16,19,45,46,49], and five studies of more varied sizes (n = 19-336) addressed irritant hand dermatitis [18,24,25,47,48]. In eight studies, emollient treatment reduced TEWL significantly, by 1.7 to 12.2 g/ m 2 h. The remaining four studies failed to show significant effects, but the point estimates in two of them [19,46] were clearly in favor of moisturizer treatment, and the non-significant results may to some extent represent a lack of statistical power.…”