Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review

Lindh, Jonatan D.; Bradley, J. F. N.

doi:10.1007/s40257-015-0146-4

Cited by 67 publications

(67 citation statements)

References 51 publications

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“…Thus, conclusions about the role of the active ingredients should be made cautiously. [24] Nevertheless, topical agents containing immunosuppressive agents and bactericidal agents appear to have an efficacy superior to moisturizer alone.…”

Section: Discussionmentioning

confidence: 99%

High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis

Sun

et al. 2017

Chinese Medical Journal

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Background:Seborrheic dermatitis (SD) is a common inflammatory skin condition. The etiology is unclear, although overgrowth of Malassezia on the skin has been suggested to cause SD. This study investigated whether colonization with Staphylococcus plays a role in facial SD, which was not well addressed previously.Methods:The study was conducted from September 1, 2011 to February 20, 2012 in the First Hospital of China Medical University. In the first phase, the study evaluated the level of transepidermal water loss (TEWL) and the number of colony-forming units (CFU) of Staphylococcus in defined skin areas of SD patients who were human immunodeficiency virus (HIV) seropositive (HIV [+] SD [+] group, n = 13), classical SD (HIV [−] SD [+] group, n = 24) patients, HIV seropositive-non-SD (HIV [+] SD [−] group, n = 16) patients, and healthy volunteers (HIV [−] SD [−] group, n = 16). In the second phase, we enrolled another cohort of HIV (−) SD (+) patients who applied topical fusidic acid (n = 15), tacrolimus (n = 16), or moisturizer (n = 12). Changes in the Seborrheic Dermatitis Area Severity Index (SDASI), TEWL, and Staphylococcus density were evaluated 2 weeks later. Comparisons of each index were performed using analysis of variance (ANOVA) and least significant difference method.Results:The level of TEWL was greater through lesional sites in the HIV (+) SD (+) group than that in HIV (+) SD (−) and HIV (−) SD (−) groups (95% confidence interval [CI]: 18.873–47.071, P < 0.001 and 95% CI: 28.755–55.936, P < 0.001, respectively). The number of CFU of Staphylococcus was greater in the HIV (+) SD (+) group than that in HIV (+) SD (−) and HIV (−) SD (−) groups (95% CI: 37.487–142.744, P = 0.001 and 95% CI: 54.936–156.400, P < 0.001, respectively). TEWL was significantly more improved in patients treated with tacrolimus and fusidic acid than that in those treated with moisturizers (95% CI: 7.560–38.987, P = 0.004 and 95% CI: 4.659–37.619, P = 0.011, respectively). Topical tacrolimus and fusidic acid were significantly associated with decreased SDASI as compared with moisturizer (95% CI: 0.03–0.432, P = 0.025 and 95% CI: 0.033–0.44, P = 0.024, respectively).Conclusions:High colonization with Staphylococcus epidermidis, along with impaired skin permeability barrier function, contributes to the occurrence of SD.

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Section: Discussionmentioning

confidence: 99%

High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis

Sun

et al. 2017

Chinese Medical Journal

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“…Given that glycerin promotes hydration of the stratum corneum, it also decreases transepidermal water loss (Table ). Glycerin, too, is clinically effective against pruritus .…”

Section: Basic Skin Care (Basic Therapy)mentioning

confidence: 99%

“…Indem Glycerin die Hydratisierung des Stratum corneum fördert, kommt es zugleich zu einem verringerten transepidermalen Wasserverlust (Tabelle 1 ). Auch Glycerin zeigt klinisch juckreizlindernde Wirkung [ 17 ] .…”

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Basic skin care in atopic dermatitis – new and established treatment options

Chylla

Schnopp

Volz

2018

J Deutsche Derma Gesell

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SummaryBasic skin care (basic therapy) is a mainstay in the treatment of atopic dermatitis, irrespective of disease severity and current disease activity. Consistent application of basic skin care plays a key role in restoring skin barrier function and reducing xerosis as well as pruritus. Moreover, it has been shown that concurrent basic therapy has steroid-sparing effects in acute disease flares. In long-term atopic dermatitis management, the use of basic skin care is associated with prolonged recurrence-free intervals. Recent studies have also demonstrated that early initiation of basic skin therapy has protective effects in infants at risk of developing atopic dermatitis. The present review addresses these topics with a focus on established treatments and new developments.

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“…Indem Glycerin die Hydratisierung des Stratum corneum fördert, kommt es zugleich zu einem verringerten transepidermalen Wasserverlust (Tabelle ). Auch Glycerin zeigt klinisch juckreizlindernde Wirkung .…”

Section: Basistherapieunclassified

Basistherapie bei atopischer Dermatitis – Neues und Bewährtes

Chylla¹,

Schnopp²,

Volz³

2018

J Deutsche Derma Gesell

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Zusammenfassung Die Basistherapie stellt eine tragende Säule in der Behandlung der atopischen Dermatitis dar. Sie ist unabhängig vom Schweregrad der Erkrankung in allen Stadien indiziert. Eine konsequente Basistherapie trägt entscheidend zur Wiederherstellung der gestörten Barrierefunktion, zur Reduktion der Xerosis und des Juckreizes bei. Überdies konnte eine Einsparung von topischen Steroiden durch eine gleichzeitig durchgeführte Basistherapie bei akuter atopischer Dermatitis gezeigt werden. Im Langzeitmanagement der Erkrankung führt sie zu einem verlängerten rezidivfreien Intervall. Neuere Studien zeigen einen protektiven Effekt einer früh begonnenen Basistherapie hinsichtlich der Entwicklung einer atopischen Dermatitis. Im folgenden Review sollen diese Aspekte unter Berücksichtigung klassischer Basistherapeutika und neuerer Entwicklungen aufgezeigt werden.

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Clinical Effectiveness of Moisturizers in Atopic Dermatitis and Related Disorders: A Systematic Review

Abstract: The clinical effect of moisturizers is well-documented. Urea-based preparations may be preferable as a first-line treatment, but there is an unmet need for well-powered comparisons between individual moisturizers.

Cited by 67 publications

References 51 publications

High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis

High Staphylococcus epidermidis Colonization and Impaired Permeability Barrier in Facial Seborrheic Dermatitis

Basic skin care in atopic dermatitis – new and established treatment options

Basistherapie bei atopischer Dermatitis – Neues und Bewährtes

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