Emollients and moisturisers for eczema

Zuuren, Esther J van; Fedorowicz, Zbys; Christensen, Robin; Lavrijsen, A.P.M.; Arents, B.W.M.

doi:10.1002/14651858.cd012119.pub2

Cited by 139 publications

(173 citation statements)

References 204 publications

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“…The number of arms on which a relapse occurred was considered the primary outcome of the present study. The variations and methodological difficulties regarding the definition of flare, or relapse, have been the focus of systematic reviews and recent publications that have aimed to validate measures for long-term disease control in prospective interventions of AD (51)(52)(53). As the individual threshold and perceived need for treatment may vary and consequently, impact behaviour, we used a symptom-based definition that was comprehensible and easily captured by the participants, while reflecting the escalation of symptoms and increased inflammatory activity, in case a relapse occurred.…”

Section: Discussionmentioning

confidence: 99%

Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

Angelova-Fischer¹,

Rippke²,

Richter³

et al. 2018

Acta Derm Venerol

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Prevention of the flares is a main goal in the long-term treatment of atopic dermatitis (AD). Therefore we investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of the flares in adults with mild to moderately severe AD, treated with topical steroids, that led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Compared with the vehicle, the active formulation significantly reduced the number of relapses and maintained the barrier homeostasis of the respective arm. To the best of knowledge, this is the first study to show prevention of the AD flares by the use of stand-alone emollient treatment, based on comparison with the corresponding vehicle while excluding concomitant/rescue medications.

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Section: Discussionmentioning

confidence: 99%

Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

Angelova-Fischer¹,

Rippke²,

Richter³

et al. 2018

Acta Derm Venerol

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“…Four SRs were found assessing emollients in AE, although three related to a single Cochrane review by van Zuuren et al . This included a large number of studies (77 RCTs, 6603 participants), but many had a high risk of bias.…”

Section: Drug Therapies For Atopic Eczemamentioning

confidence: 99%

What's new in atopic eczema? An analysis of systematic reviews published in 2017. Part 1: treatment and prevention

et al. 2019

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This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE). It provides a summary of key findings from 25 systematic reviews that were published or indexed during 2017, and focuses on the treatment and prevention of AE. There is high-quality evidence to demonstrate that dupilumab is better than placebo for the treatment of AE, is not associated with a higher incidence of adverse effects and does not increase the risk of infection compared with placebo; however, comparison studies with other systemic treatments are necessary. Topical tofacitinib is a promising treatment for mild-moderate AE, but currently lacks sufficient evidence from well-designed randomized controlled trials (RCTs) comparing with other active treatments. Topical doxepin may be effective for pruritus in AE, but available studies have short follow-up periods and longer-term outcomes are needed. Bleach baths were no more effective than water baths alone at reducing AE severity. Topical antibiotics cannot be recommended for infected AE, owing to insufficient evidence of benefit. There is little comparison of different emollients in RCTs, but overall evidence indicates that they reduce AE severity, are steroid-sparing and lead to better outcomes in combination with topical corticosteroids (TCS) than TCS alone. No clear benefit was demonstrated for vitamin D/C/E supplementation in pregnancy for eczema prevention.

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“…Only one article was removed over duplication. Further 18 articles were excluded (Bjelakovic et al, 2012;Chen & Lina, 2016;Consales et al, 2014;Farquhar et al, 2017;Garolla et al, 2014;Hart et al, 2015;Li et al, 2016;MacArthur et al, 2014;Nicoletti et al, 2016;Nisenblat et al, 2016;Pourmand et al, 2014;Povey et al, 2012;Rubes et al, 1998;Showell et al, 2013;Showell et al, 2014;Skalkidou et al, 2017;Van et al, 2017;Varshini et al, 2012) after reviewing the titles and abstracts. Full papers were obtained for the remaining 5 articles and reviewing were done thoroughly (Figure 1).…”

Section: Studies Selectedmentioning

confidence: 99%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: 'alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet' AND 'sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine' were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

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Emollients and moisturisers for eczema

Cited by 139 publications

References 204 publications

Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study

What's new in atopic eczema? An analysis of systematic reviews published in 2017. Part 1: treatment and prevention

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

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