Bionic artificial penile Tunica albuginea

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

“…So treatment of non-invasive transdermal approach deserves further exploration. 4) The existing studies on hydrogel therapy for ED are based on small animals, only one study has applied the model of pigs [ 16 ], there is still a long way to go before they can be extended to clinical applications. The use of hydrogels not only optimizes existing drug delivery methods but also improves or cures some refractory organic ED.…”

“…In addition, a recent study showed that a bionic artificial penile TA made by hydrogel patches displayed the capability to restore normal erectile function of the TA-damaged penile tissue in a pig model [ 16 ]. This kind of hydrogel patches composed of a strain-stiffening hydrogel consisting of aligned yet crimped fibers, which possess several key mechanical features of natural TA, including rapid strain stiffening over small intervals of deformation, excellent fatigue resistance to sustain cyclic bursts, and high toughness to withstand pointwise acupuncture during suturing.…”

“…Instead, hydrogels offer a number of advantages over existing therapies. They can be synthesized from various raw materials with different properties, possess a definite composition, and have tunable mechanical properties [ 16 ]. Good biocompatibility and biodegradability also make them an effective drug carrier [ 17 ].…”

Hydrogel-Based Sensors for Human–Machine Interaction

“…(c) Bionic artificial tunica albuginea. Reproduced with permission from ref . Copyright 2023 Elsevier.…”

Artificial tissue: a future surgical approach for reversing erectile dysfunction – correspondence

“…Chai et al . 7 have developed bionic TA [artificial tunica albuginea (ATA)]. It can stretch and relax in short bursts repeatedly without becoming tired or losing its tensile strength, and it can even survive needle pricks during suturing.…”