Biomedical applications of polymers 2001 - 2002

Jagur‐Grodzinski, J.

doi:10.1515/epoly.2003.3.1.141

Cited by 31 publications

(38 citation statements)

References 67 publications

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“…Nature's way to carry genes is viruses and these were the first carriers used for gene delivery [36,37]. However viruses have many disadvantages, the most severe of which is the immune response that they can cause and this is why non-viral carriers have been developed [36][37][38][39][40][41]. Many of these are polymer-based because polymers are cheaper and safer than viruses and also easier to tailor compared to other gene delivery carriers like liposomes [36][37][38]42].…”

Section: Gene Deliverymentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Gene Deliverymentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…The above-mentioned polymers, degradable hydrolytically to non-toxic bioabsorbable hydroxyacids, were used as sutures, plates and screws for bone fixation [1,2]. There are many reports on drug formulations in which poly(D,L-lactide-co-glycolide) (PLGA) nano-and microspheres were used as drug carriers [2][3][4][5][6][7][8]. Bioactive compounds in these formulations are protected by the polyester matrix from degrading enzymes and immuno-defence system.…”

Section: Introductionmentioning

confidence: 99%

Poly(L,L-lactide) and poly(L,L-lactide-co-glycolide) microparticles by dialysis

2005

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Formation of poly(L,L-lactide) (PLLA) and poly(D,L-lactide-co-glycolide) (PLGA) microparticles by dialysis from 1,4-dioxane, tetrahydrofuran (THF), acetonitrile, dimethyl sulfoxide (DMSO), and dimethylformamide (DMF) against water has been investigated. In some instances microparticles were obtained from a mixture of the above-mentioned polyesters and PLLA-block-polyglycidol-blockpoly(ethylene oxide) triblock copolymer containing a hydrophobic PLLA block as well as hydrophilic polyglycidol and poly(ethylene oxide) blocks, the former with functional -OH groups. The effects of the nature of polyester, solvent and concentration of triblock copolymer on particles morphology, size, size distribution, and degree of crystallinity have been determined. Dialysis of PLGA yielded particles in the form of microspheres regardless of the solvent. Diameters of these particles were in the range of 0.36 -1.77 µm and particles' diameter polydispersity ( D ) varied from 1.37 to 2.04, depending on the solvent. In the case of PLLA, microspheres were obtained only by dialysis from 1,4-dioxane solutions. Dialysis of PLLA solutions in THF, acetonitrile and DMF yielded particles in the form of microcrystals. In the case of dialysis of PLLA solutions in DMSO, the product was in form of crystalline flakes of c. 1 µm thickness. Microspheres composed of PLGA were amorphous. The degree of crystallinity of microparticles from PLLA was in the range of 39% -72%.

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“…The unique characteristics of chitosan like acts as replacement for missing or damaged tissue [41] and supporting cell attachment and proliferation will make suitable for tissue engineering applications [42]. Chitosan has favourable conditions like low immuno-genic activity, controlled biodegradability and porous structure for tissue engineering applications.…”

Section: Chitosan With Drug Formulations In Tissue Engineering Applicmentioning

confidence: 99%

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

Kashyap

Archana

Semwal³

et al. 2015

Springer Series on Polymer and Composite Materials

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Chitosan plays a most important role in the regenerative medication for wound healing. The adhesive nature of chitosan, with their antifungal and bactericidal character, and their permeability to oxygen, is a very important property associated with the treatment of wounds. Different derivatives and combination of chitosan have been reported for this purpose in the form of hydrogels, fibers, membranes, scaffolds and sponges. The purpose of the chapter is to have a closer look in the work done directly by different researchers on the chitosan formulation with potential medicinal applications to provide a better understanding of its usability in regenerative medicine.

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Biomedical applications of polymers 2001 - 2002

Cited by 31 publications

References 67 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

Poly(L,L-lactide) and poly(L,L-lactide-co-glycolide) microparticles by dialysis

Chitosan: A Promising Substrate for Regenerative Medicine in Drug Formulation

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