Biomaterials: Foreign Bodies or Tuners for the Immune Response?

Mariani, Erminia; Lisignoli, Gina; Borzı̀, Rosa Maria; Pulsatelli, Lia

doi:10.3390/ijms20030636

Cited by 463 publications

(432 citation statements)

References 392 publications

(441 reference statements)

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“…In seemingly all applied cases, it is important to minimize any immune response to the hydrogel injection. Immunological responses are responsible for adverse outcomes of biomaterial injection or implantation, including inflammation and fibrosis 52 . While these responses are deleterious in their own right, their associated physicochemical shifts (i.e., changes in the local pH or temperature) can also alter the hydrogel material, impairing function further.…”

Section: Design Challengesmentioning

confidence: 99%

Hydrogels in the clinic

Mandal

Clegg

Anselmo

et al. 2020

Bioengineering & Transla Med

270

241

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Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels' versatility arises from their tunable structure, which has been enabled by considerable advances in fields such as materials engineering, polymer science, and chemistry. Advances in these fields continue to lead to invention of new polymers, new approaches to crosslink polymers, new strategies to fabricate hydrogels, and new applications arising from hydrogels for improving healthcare. Various hydrogel technologies have received regulatory approval for healthcare applications ranging from cancer treatment to aesthetic corrections to spinal fusion. Beyond these applications, hydrogels are being studied in clinical settings for tissue regeneration, incontinence, and other applications. Here, we analyze the current clinical landscape of injectable hydrogel technologies, including hydrogels that have been clinically approved or are currently being investigated in clinical settings. We summarize our analysis to highlight key clinical areas that hydrogels have found sustained success in and further discuss challenges that may limit their future clinical translation. K E Y W O R D S clinics, drug delivery, FDA, injectable materials, marketed products, regenerative, translational medicine

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Section: Design Challengesmentioning

confidence: 99%

Hydrogels in the clinic

Mandal

Clegg

Anselmo

et al. 2020

Bioengineering & Transla Med

270

241

View full text Add to dashboard Cite

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“…The interaction of cells with the implants takes place at the sub-micrometer level. Some studies prove that the anisotropic structure considerably improves the integration of the bone [12,13]. Micrographs of the coating show a rough and porous topography that is formed by the accumulation of coarse incompletely melted Ti powder particles.…”

Section: Results Of Coatings Testingmentioning

confidence: 99%

The mechanical and microstructural properties of VPS-Ti porous coating deposited on titanium alloy substrates for osseointegration

Mrdak¹,

Lačnjevac²,

Rakin³

et al. 2020

Zaštita materijala

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The topography of the surface of the deposited VPS-Ti coatings on substrate surfaces of implants relating to the roughness and porous structure plays a decisive role in the process of on growth of the implants to the bones i.e.osseointegration. Direct bone on growth has been successfully achieved by using micro rough coating surfaces, such as the use of vacuum plasma spraying VPS -Ti coatings. The aim of this study was to make a comprehensive review of the characterization of porous VPS-Ti coatings deposited on substrates of titanium alloy that will find application in orthopedics.One of the preferred features of the VPS process is the ability to achieve optimum macro and micro structure of the surface of implants by optimizing the spray parameters of the powder deposition and by the range of the powder granulation. In order to achieve an optimum surface roughness, open porosity and structure of VPS-Ti coatings conducted was the optimization of deposition of powder with a change in plasma current and powder carrier gas flow rate of (700 A, 35 l/min and 800A, 20 l/min). Lower intensity plasma current with a greater flow of powder heats and melts the powder particles less forming micro pores of a larger size and a higher proportion of open pores and vice versa higher plasma currents and reduced flow provide better melted particles forming a smaller share of micro pores and open porosity in the deposited layers. Image analysis showed that by optimization of parameters in the coatings open porosity can be formed ranging from 45% to 57%. By examining the properties of the deposited layers it was determined that the most optimal roughness and share of open pores for osseointegration have the Ti layers which have been deposited with the lowest amperage and highest flow of powder carrier gas.

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“…An important finding in this study was the formation of granulomas in the membrane group. Mariani et al 27 suggested that this foreign body reaction represents chronic inflammation comprised mainly of multinucleated giant cells and can occur in response to the implantation of a biomaterial. However, it cannot be concluded that the granulomas observed in this study were produced due to membrane features or immunological responses in recipient animals since they were not detected in the membrane groups at days 7 and 14.…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats

et al. 2019

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Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair. Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. Results: Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p < 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p < 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107). Conclusion: Treatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats Nascimento LDS et al. Acta Cir Bras. 2019;34(11):e201901101Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats Nascimento LDS et al. Cir Bras. 2019;34(11):e201901101 ActaEffect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats Nascimento LDS et al.

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Biomaterials: Foreign Bodies or Tuners for the Immune Response?

Cited by 463 publications

References 392 publications

Hydrogels in the clinic

Hydrogels in the clinic

The mechanical and microstructural properties of VPS-Ti porous coating deposited on titanium alloy substrates for osseointegration

Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats

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