Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

Kunert‐Keil, Christiane; Gredes, Tomasz; Gedrange, Tomasz

doi:10.5772/18459

Cited by 7 publications

(10 citation statements)

References 185 publications

(144 reference statements)

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“…Calcium phosphate ceramics include a variety of ceramics, such as hydroxyapatite, tricalcium phosphate, and calcium phosphate cement. These mentioned ceramics have either excellent biocompatibility, bone bonding or bone regeneration properties [22].…”

Section: Synthetic Bone Graft (Alloplastic Grafts)mentioning

confidence: 99%

Perspectives on regeneration of alveolar bone defects

et al. 2013

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Section: Synthetic Bone Graft (Alloplastic Grafts)mentioning

confidence: 99%

Perspectives on regeneration of alveolar bone defects

et al. 2013

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“…Some osteoblasts differentiate into osteoid and attach to the matrix. 5 It can be said that bone mass is regulated through a remodeling process involving two phases, namely; bone formation by osteoblasts and bone resorption by osteoclasts. 6 In the field of prosthodontics, maintaining alveolar bone after tooth extraction should be prioritized to support the manufacture of conventional prostheses as well as the placement of implants.…”

Section: Introductionmentioning

confidence: 99%

Effects of hydroxyapatite gypsum puger scaffold applied to rat alveolar bone sockets on osteoclasts, osteoblasts and the trabecular bone area

Naini¹,

Sudiana²,

Rubianto³

et al. 2019

Dent. J.

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Background: Damage to bone tissue resulting from tooth extraction will cause alveolar bone resorption. Therefore, a material for preserving alveolar sockets capable of maintaining bone is required. Hydroxyapatite Gypsum Puger (HAGP) is a bio-ceramic material that can be used as an alternative material for alveolar socket preservation. The porous and rough surface of HAGP renders it a good medium for osteoblast cells to penetrate and attach themselves to. In general, bone mass is regulated through a remodeling process consisting of two phases, namely; bone formation by osteoblasts and bone resorption by osteoclasts. Purpose: This research aims to identify the effects of HAGP scaffold application on the number of osteoblasts and osteoclasts, as well as on the width of trabecular bone area in the alveolar sockets of rats. Methods: This research used Posttest Only Control Group Design. There were three research groups, namely: a group with 2.5% HAGP scaffold, a group with 5% HAGP scaffold and a group with 10% HAGP scaffold. The number of samples in each group was six. HAGP scaffold at concentrations of 2.5%, 5% and 10% was then mixed with PEG (Polyethylene Glycol). The Wistar rats were anesthetized intra-muscularly with 100 mg/ml of ketamine and 20 mg/ml of xylazine base at a ratio of 1:1 with a dose of 0.08-0.2 ml/kgBB. Extraction of the left mandibular incisor was performed before 0.1 ml preservation of HAGP scaffold + PEG material was introduced into the extraction sockets and suturing was performed. 7 days after preparation of the rat bone tissue, an Hematoxilin Eosin staining process was conducted in order that observation under a microscope could be performed. Results: There were significant differences in both the number of osteoclasts and osteoblasts between the 2.5% HAGP group, the 5% HAGP group and the 10% HAGP group (p = 0.000). Similarly, significant differences in the width of the trabecular bone area existed between the 5% HAGP group and the 10% HAGP group, as well as between the 2.5% HAGP group and the 10% HAGP group (p=0.000). In contrast, there was no significant difference in the width of the trabecular bone area between the 2.5% HAGP group and the 5% HAGP group. Conclusion: The application of HAGP scaffold can reduce osteoclasts, increase osteoblasts and extend the trabecular area in the alveolar bone sockets of rats.

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“…In the fields of orthopedics, neurosurgery and dentistry, bone grafts are used in order to reconstruct bone defects and stimulate bone healing after trauma and bone loss. 1,2 There are several methods of bone transplantation; they include the use of autologous, allogeneic and xenogeneic bone tissues, as well as synthetic bone substitutes. Autologous bone is harvested from the patient's own body, while allografts are obtained from a bone bank.…”

Section: Introductionmentioning

confidence: 99%

“…Synthetic variants can be created from ceramics, coralline hydroxyapatite, bioactive glasses, glass ionomers, and biological/synthetic composite grafts. [1][2][3] The use of synthetic bioactive bone substitute materials is of keen interest in modern dentistry as an alternative to autogenous bone grafts.…”

Section: Introductionmentioning

confidence: 99%

“…Calcium phosphate cements, such as Cerasorb ® (Curasan AG, Frankfurt am Main, Germany) or Straumann Bone Ceramic ® (Straumann Holding AG, Basel, Switzerland), currently play a secondary role in dentistry. 2 It is well known that plants and animals naturally produce a variety of polymers which can serve as a solid source for biomaterials, such as collagen, silk or cellulose. 2,6 The use of vegetable fibers in polymeric composites, in particular bast fibers from flax, hemp or jute, has been reported in many studies.…”

Section: Introductionmentioning

confidence: 99%

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Histological examinations of the in vivo biocompatibility of oxycellulose implanted into rat skeletal muscle

Kunert‐Keil¹,

Narath²,

Hadzik³

et al. 2018

Adv Clin Exp Med

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Background. Recently it was shown that oxycellulose suppressed bone regeneration led to an accumulation of connective tissue as well as foam cells in bone defects. Objectives. Since oxycellulose can be used as a hemostatic agent in general and dental surgery, the aim of the study was to examine muscle tissue response to implanted oxidized cellulose. Material and methods. RESO-Cell® (Resorba Wundversorgung GmbH, Nuremberg, Germany) standard was implanted in the latissimus dorsi of 20 rats; subsequently, 12 samples were processed for histological evaluation after 4 and 8 weeks. The remaining 8 samples were processed for mRNA expression analyses of gene-encoding growth factors and collagens using quantitative reverse transcription polymerase chain reaction (RT-qPCR). Results. Muscle tissue exposed to oxycellulose showed elevated mRNA levels of COL1A1 compared to untreated muscle tissue. The histological analysis revealed that no undegraded oxycellulose was detectable after as little as 4 weeks. Furthermore, a strong accumulation of CD68-positive foam cells was found in the treated area. Conclusions. In conclusion, the study has shown that oxidized cellulose can cause an inflammatory response after this material is implanted in skeletal muscle. Therefore, it is not recommended to leave this material in the body over a long period. However, it could be used as auxiliary material in the treatment of periodontal defects.

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Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

Cited by 7 publications

References 185 publications

Perspectives on regeneration of alveolar bone defects

Perspectives on regeneration of alveolar bone defects

Effects of hydroxyapatite gypsum puger scaffold applied to rat alveolar bone sockets on osteoclasts, osteoblasts and the trabecular bone area

Histological examinations of the in vivo biocompatibility of oxycellulose implanted into rat skeletal muscle

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