Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome

Dambala, Kalliopi; Paschou, Stavroula Α.; Michopoulos, Alexandros; Siasos, Gerasimos; Goulis, Dimitrios G.; Vavilis, Dimitrios; Tarlatzis, Basil C.

doi:10.1177/0003319719840091

Cited by 24 publications

(24 citation statements)

References 70 publications

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“…It has been reported that circulating levels of visfatin and its gene expression were increased in women with PCOS, compared with controls matched by BMI and age (58) . Visfatin has been identified as a protein of 52 kDa produced by the bone marrow, liver and muscle and, during pregnancy, by the epithelium of the amniotic membrane, chorionic trophoblast and decidua (58) . Years later, it was proven that visfatin is produced by adipocytes and has insulin-mimetic action (59) .…”

Section: Discussionmentioning

confidence: 99%

Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

et al. 2020

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Polycystic ovary syndrome (PCOS) is defined as a reproductive endocrine disease that results in a low-grade inflammatory and prooxidant state. Dietary factors, including omega-3 fatty acids, may have a key role in improving metabolic disorders in PCOS patients. The present study aimed to investigate the influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with PCOS. A systematic literature search of Medline/PubMed, Cochrane Central Register of Controlled Trials, Scopus and Lilacs, until November 2019, was conducted. Randomized clinical trials that reported inflammatory and oxidative stress markers as endpoints in women with PCOS receiving omega-3 fatty acid supplementation were included. The pooled estimates of the weighted mean differences (WMD) and the standard mean differences (SMD) were calculated. Random effect models were adopted to measure the pooled outcomes. Among the 323 studies retrieved, 10 fulfilled the inclusion criteria for a meta-analysis. We founded a significant decrease in high-sensitivity C-reactive protein (hs-CRP) [SMD: −0.29 (95%CI: −0.56 to −0.02) mg/L] and an increase of adiponectin [WMD: 1.42 (95%CI 1.09 to 1.76) ng/ml] concentrations in the intervention group when compared with the placebo group. No statistically significant results were found in the meta-analysis for visfatin, nitric oxide (NO), glutathione (GSH) or malondialdehyde (MDA) levels or total antioxidant capacity (TAC). The data suggest that supplementation of omega-3 fatty acids could reduce the inflammatory state in women with PCOS, through a decrease in hs-CRP and an increase in adiponectin levels.

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Section: Discussionmentioning

confidence: 99%

Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

et al. 2020

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“…VEGF protein is known to be closely related to the pathogenesis of PCOS. Serum VEGF levels are significantly elevated in PCOS patients [16][17][18]. High levels of serum VEGF result in a higher number of active granuloas lutein cells (GLCs), increase secretion of GLCs, and up-regulate VEGF gene expression [40].…”

Section: Discussionmentioning

confidence: 99%

“…Vascular endothelial growth factor (VEGF), a homodimeric glycoprotein hormone first purified by Ferrara et al from the bovine pituitary follicular stellate cells in vitro, is the most active angiogenic factor ever known, which can maintain the differentiation state of vascular endothelial cells and improve microvascular permeability, and play a powerful regulatory role in the occurrence and development of various diseases [14,15]. It is closely related to the pathogenesis of PCOS, and studies have reported a significant rise in serum level of VEGF in the PCOS patients [16][17][18]. Additionally, the overexpression of VEGF gene in the polycystic ovarian stroma also reveals the critical role of this gene in the pathophysiology of PCOS [19].…”

Section: Introductionmentioning

confidence: 99%

Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

Zhao

Tang

et al. 2020

Reprod Biol Endocrinol

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Background: Polycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors. Previous studies have shown that vascular endothelial growth factor (VEGF) gene polymorphisms are associated with the risk of polycystic ovarian syndrome. However, the results of these studies remain controversial. We performed the present meta-analysis aiming to further investigate the potential relationship between VEGF polymorphisms and susceptibility to PCOS. Methods: The following databases were systematically searched: PubMed, EMBASE, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), and Wanfang Databases. The correlation between VEGF polymorphisms and PCOS risk was assessed by calculating pooled odds ratios (ORs) and their 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were also conducted. Besides, trial sequential analysis (TSA) was done to verify the reliability of the pooled results. Results: 10 relevant case-control studies were incorporated in this meta-analysis, involving 1347 PCOS cases and 1378 controls. The VEGF rs2010963 polymorphism was associated with decreased PCOS risk in the whole population and the Asian populations. The VEGF rs3025039 polymorphism was associated with decreased PCOS susceptibility and the Asian populations, but increased risk of PCOS was observed among the Caucasian populations. In addition, the results of trial sequential analysis (TSA) showed the negative correlation between rs2010963 and PCOS risk, obtained by our meta-analysis, was stable and reliable. Conclusion: Overall, different VEGF gene polymorphisms may exert different effects on PCOS susceptibility. The VEGF rs2010963 polymorphism decreases PCOS susceptibility in both the whole population and the Asian populations, and VEGF rs3025039 polymorphism causes lower PCOS susceptibility in the whole population and the Asian populations but higher in the Caucasian populations.

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“…Moreover, PCOS women have reduced EPCs number and function, likely due to increased ROS levels and impaired insulin signaling [214]. Finally, other biomarkers of endothelial dysfunction are increased in women with PCOS, such as visfatin, VEGF, matrix metallopeptidase 9 (MMP9), highmobility group box 1, pentraxin 3, and soluble lectin-like oxidized low-density lipoprotein receptor-1 [215].…”

Section: Endothelial Dysfunction Markers In Polycystic Ovary Syndromementioning

confidence: 99%

The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility

Santi

Spaggiari

Greco

et al. 2021

IJMS

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Endothelial dysfunction is an early event in the pathogenesis of atherosclerosis and represents the first step in the pathogenesis of cardiovascular diseases. The evaluation of endothelial health is fundamental in clinical practice and several direct and indirect markers have been suggested so far to identify any alterations in endothelial homeostasis. Alongside the known endothelial role on vascular health, several pieces of evidence have demonstrated that proper endothelial functioning plays a key role in human fertility and reproduction. Therefore, this state-of-the-art review updates the endothelial health markers discriminating between those available for clinical practice or for research purposes and their application in human fertility. Moreover, new molecules potentially helpful to clarify the link between endothelial and reproductive health are evaluated herein.

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Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome

Cited by 24 publications

References 70 publications

Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility

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