Association of vascular endothelial growth factor polymorphisms with polycystic ovarian syndrome risk: a meta-analysis

Abstract

Background: Polycystic ovarian syndrome (PCOS) is a multi-gene hereditary disorder caused by the interaction of certain gene variation with environmental factors. Previous studies have shown that vascular endothelial growth factor (VEGF) gene polymorphisms are associated with the risk of polycystic ovarian syndrome. However, the results of these studies remain controversial. We performed the present meta-analysis aiming to further investigate the potential relationship between VEGF polymorphisms and susceptibility to PCOS. Methods: The following databases were systematically searched: PubMed, EMBASE, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), and Wanfang Databases. The correlation between VEGF polymorphisms and PCOS risk was assessed by calculating pooled odds ratios (ORs) and their 95% confidence intervals (95% CIs). Subgroup analyses stratified by ethnicity and source of control were also conducted. Besides, trial sequential analysis (TSA) was done to verify the reliability of the pooled results. Results: 10 relevant case-control studies were incorporated in this meta-analysis, involving 1347 PCOS cases and 1378 controls. The VEGF rs2010963 polymorphism was associated with decreased PCOS risk in the whole population and the Asian populations. The VEGF rs3025039 polymorphism was associated with decreased PCOS susceptibility and the Asian populations, but increased risk of PCOS was observed among the Caucasian populations. In addition, the results of trial sequential analysis (TSA) showed the negative correlation between rs2010963 and PCOS risk, obtained by our meta-analysis, was stable and reliable. Conclusion: Overall, different VEGF gene polymorphisms may exert different effects on PCOS susceptibility. The VEGF rs2010963 polymorphism decreases PCOS susceptibility in both the whole population and the Asian populations, and VEGF rs3025039 polymorphism causes lower PCOS susceptibility in the whole population and the Asian populations but higher in the Caucasian populations.

Application of Herbal Medicines for Obesity Treatment in the Polycystic Ovarian Syndrome Women

“…Polycystic Ovarian Syndrome (PCOS) in women is recognized as an endocrine disorder in reproductive-aged women 1 . PCOS is characterized by irregular menses, hyperandrogenism, micropolycystic ovaries and metabolic abnormalities 2 .…”

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

“…A meta-analysis of seven studies showed there is little association between PCOS risk and the VEGF gene polymorphisms rs2010963, rs833061, and rs699947 in the general populations, whereas the genotype CC (rs2010963) might decrease the risk of PCOS among Asian women 8 . Another recent meta-analysis included 10 relevant case-control studies, involving 1347 PCOS cases and 1378 controls.…”

“…The VEGF gene is located in the chromosome region 6p21.3 5 . Single-nucleotide polymorphisms (SNPs) have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested VEGF gene polymorphisms may be associated with PCOS risk [6][7][8] . VEGF rs833061 T and rs2010963 G alleles appear to correlate with altered VEGF expression levels.…”

Research Progress of PCNA in Reproductive System Diseases

“…The reduced expression of PCNA in cystic follicles is accompanied by downregulation of the cystic fibrosis transmembrane conductance regulator, which is required for normal follicle development and causes abnormal follicular development in PCOS [ 33 ]. GCs are the main source of VEGF production [ 34 ]. VEGF is one of the major regulators of angiogenesis and plays an important role in multiple diseases affecting the ovary, such as PCOS.…”