Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis

Abstract

Polycystic ovary syndrome (PCOS) is defined as a reproductive endocrine disease that results in a low-grade inflammatory and prooxidant state. Dietary factors, including omega-3 fatty acids, may have a key role in improving metabolic disorders in PCOS patients. The present study aimed to investigate the influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with PCOS. A systematic literature search of Medline/PubMed, Cochrane Central Register of Controlled Trials, Scopus and Lilacs, until November 2019, was conducted. Randomized clinical trials that reported inflammatory and oxidative stress markers as endpoints in women with PCOS receiving omega-3 fatty acid supplementation were included. The pooled estimates of the weighted mean differences (WMD) and the standard mean differences (SMD) were calculated. Random effect models were adopted to measure the pooled outcomes. Among the 323 studies retrieved, 10 fulfilled the inclusion criteria for a meta-analysis. We founded a significant decrease in high-sensitivity C-reactive protein (hs-CRP) [SMD: −0.29 (95%CI: −0.56 to −0.02) mg/L] and an increase of adiponectin [WMD: 1.42 (95%CI 1.09 to 1.76) ng/ml] concentrations in the intervention group when compared with the placebo group. No statistically significant results were found in the meta-analysis for visfatin, nitric oxide (NO), glutathione (GSH) or malondialdehyde (MDA) levels or total antioxidant capacity (TAC). The data suggest that supplementation of omega-3 fatty acids could reduce the inflammatory state in women with PCOS, through a decrease in hs-CRP and an increase in adiponectin levels.

Green cardamom plus low-calorie diet can decrease the expression of inflammatory genes among obese women with polycystic ovary syndrome: a double-blind randomized clinical trial

“…This 16-week trial demonstrated that green cardamom supplementation can improve anthropometric indices, androgen hormones, and inflammatory factors levels and gene expression in PCOS patients with low-calorie diet. PCOS patients suffer from low-grade systemic inflammation that potentially affects their disease progression [ 22 ]. To the best of our knowledge, this is the first study that has evaluated the effects of green cardamom on anthropometric indices, androgen hormones, and inflammatory factors levels and gene expression in PCOS patients with low-calorie diet.…”

Green Cardamom Plus Low Calorie Diet Can Decrease Inflammatory Genes Expression Among Obese Women With Poly Cystic Ovarian Syndrome, A Double Blind Randomized Clinical Trial

“…This sixteen weeks trial study demonstrated the green cardamom supplementation was improved anthropometric indices, androgen hormone, inflammatory factors and genes in the PCOS women with low calorie diet. PCOS women suffer from low-grade systemic inflammation that potentially affects their disease progression [17]. To best our knowledge this is first study was evaluated the effects of green cardamom on anthropometric indices, androgen hormone, inflammatory factors and genes in the PCOS women with low calorie diet.…”

Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review

“…Recently, Tosatti and colleagues [ 99 ] studied the influence of omega-3 fatty acid supplementation on inflammatory and oxidative stress markers in PCOS patients, through a systematic literature search of Medline/PubMed, Cochrane Central Register of Controlled Trials, Scopus, and Lilacs, until November 2019. They retrieved data from 323 studies suggesting that supplementation with omega-3 fatty acids could reduce the inflammatory state in PCOS women, due to decreased high-sensitivity C-reactive protein (hs-CRP) and increased adiponectin levels [ 99 ].…”