Biological functions of allantoin

Шестопалов, А. В.; Шкурат, Т. П.; Микашинович, З. И.; Kryzhanovskaia, I O; Bogacheva, M A; Lomteva, S.V.; Prokof'ev, V P; Gus'kov, E. P.

doi:10.1134/s1062359006050037

Cited by 41 publications

(46 citation statements)

References 16 publications

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“…Moreover, it is also possible that the extracts of P. venusta could be inducing an increase in the expression of tyrosinase enzyme, without affecting its activity, which would also result in a raise in melanogenesis. The detected compound allantoin has been widely described in the literature to have several pharmacological activities, such as stimulation of cell mitosis (Loots et al, 1979), analgesia (Shestopalov et al, 2006), keratolytic activity (Veraldi et al, 2008), anti-inflammatory (Lee et al, 2010), antipsoriase, and immunostimulant, and it is widely employed in dermatology (Ferreira et al, 2000). Araujo et al (2010) suggest that allantoin modulates the inflammatory response, possibly by inhibiting the chemotaxis of inflammatory cells in the site of the wound, thus preventing the release of reactive species responsible for the oxidative stress and tissue damage.…”

Section: Discussionmentioning

confidence: 98%

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma

Moreira

Horinouchi

Souza-Filho

et al. 2012

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 98%

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma

Moreira

Horinouchi

Souza-Filho

et al. 2012

Journal of Ethnopharmacology

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“…The allantoin (Figure 1), 5-ureide-hydantoin, has been widely cited in literature as holder of numerous pharmacological activities, among them: wound healing 6,7 , anti-irritating, hydrating and remover of necrotic tissue 6 , stimulating the cell mitosis 8 ; as well as promoter of epithelial stimulation, analgesic action 9 and keratolytic activity 10 . For all these reports, the allantoin has been used in cosmetic and pharmaceutical preparations for over 70 years with different therapeutic purposes and especially as a wound healing booster.…”

Section: Introductionmentioning

confidence: 99%

Profile of wound healing process induced by allantoin

et al. 2010

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Purpose:To evaluate and characterize the wound healing process profile induced by allantoin incorporated in soft lotion oil/water emulsion using the planimetric and histological methods. Methods: Female Wistar rats (n=60) were randomly assigned to 3 experimental groups: (C) control group-without treatment; (E) group treated with soft lotion O/W emulsion excipients; (EA) group treated with soft lotion O/W emulsion containing allantoin 5%. The emulsions either containing or not allantoin were topically administered for 14 days and the wound area was evaluated by planimetry and by qualitative and quantitative histological analysis of open wound model. Results:The data which were obtained and analyzed innovate by demonstrating, qualitatively and quantitatively, by histological analysis, the profile of healing process induced by allantoin. The results suggest that the wound healing mechanism induced by allantoin occurs via the regulation of inflammatory response and stimulus to fibroblastic proliferation and extracellular matrix synthesis. Conclusion: This work show, for the first time, the histological wound healing profile induced by allantoin in rats and demonstrated that it is able to ameliorate and fasten the reestablishment of the normal skin. Key words: Wound Healing. Allantoin. Histology. Animal Experimentation. Rats. RESUMOObjetivo: Avaliar e caracterizar o perfil cicatricial induzido pela alantoína incorporada em uma emulsão óleo/água, sob os aspectos planimétrico e histológico. Métodos: Ratos Wistar fêmeas (n=60) foram agrupados aleatoriamente em três grupos experimentais grupo controle -sem tratamento (C); grupo tratado com emulsão pura (E); grupo tratado com emulsão contendo 5% de alantoína (EA). As emulsões contendo ou não alantoína foram administradas topicamente durante 14 dias e a área da ferida foi avaliada por planimetria e por análise histológica qualitativa e quantitativa em modelo de ferida aberta. Resultados: Na análise planimétrica não foi observado diferenças significativas entre os grupos experimentais. Os resultados da análise histológica sugerem que o mecanismo de cicatrização induzido pela alantoína ocorre via controle da resposta inflamatória e estímulos à proliferação fibroblástica e síntese de matrix extracelular de maneira mais intensa e rapidamente em relação aos grupos controles. Conclusão: Este trabalho mostra pela primeira vez o perfil histológico de cicatrização induzido pela alantoína em ratos, demonstrando ser capaz de melhorar e acelerar o processo de reconstituição da pele. Descritores: Cicatrização de Feridas. Alantoína. Histologia. Experimentação Animal. Ratos.

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“…It is also reported to have antioxidant activity. 8 The structure of allantoin resembles that of guanidium derivatives which are known to act by binding to imidazoline receptors. The activation of the isoforms of these receptors i.e.…”

Section: Introductionmentioning

confidence: 99%

Allantoin Alleviates Male Sexual Dysfunction in Diabetic Rats through Augmenting the Level of Testosterone

Kashif¹,

Razdan²,

Jamwal³

et al. 2018

JYP

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Objective: A majority of the diabetic patients experience sexual dysfunction. The objective of the study was to investigate the effect of allantoin on sexual dysfunction in diabetic rats. Methods: Streptozotocin-induced diabetic Wistar rats were divided into 3 groups: diabetic control group, diabetes + allantoin 100 mg/kg and diabetes + allantoin 200 mg/kg. Diabetic rats were treated with allantoin for 6 weeks and were assessed for its effect on sexual behavior, blood pressure, sperm count, sperm morphology, and levels of glycosylated hemoglobin, serum testosterone, and nitrite. Effects of treatment on diabetic rats were compared with diabetic control rats and normal healthy rats. Results: Diabetes decreased sexual behavior, sperm count and levels of serum testosterone and nitrite while increased blood pressure, the level of glycosylated hemoglobin and sperm defects in comparison to healthy rats. After a 6-week treatment period, there was a significant decrease in glycosylated hemoglobin (HbA1C) and blood pressure in the allantoin treatment groups when compared to diabetic control. Also, the rats treated with allantoin performed significantly well in sexual behavioural studies with a significant increase in body weight, sperm count, and levels of serum testosterone and nitrite compared to diabetic control. Conclusion: Oral administration of allantoin improves sexual function in diabetic rats by improving glycemic control and maintaining blood pressure. It also improves sexual function in diabetic rats by preventing the reduction in levels of nitrite and serum testosterone.

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Biological functions of allantoin

Cited by 41 publications

References 16 publications

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma

Hyperpigmentant activity of leaves and flowers extracts of Pyrostegia venusta on murine B16F10 melanoma

Profile of wound healing process induced by allantoin

Allantoin Alleviates Male Sexual Dysfunction in Diabetic Rats through Augmenting the Level of Testosterone

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