Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

Abstract

Treatment of infectious diseases is an ever-increasing problem owing to the growing number of multi-drug resistant pathogens. Nosocomial infections are on the rise due to antibiotic-resistant microorganisms, which have led to increased morbidity and mortality in many hospitals. Cancer is a major disease worldwide [1] ; colorectal cancer particularly, is the second leading cause of death by cancer in Western countries and has one of the highest mortality rates in both men and women. These cancer patients are especially susceptible to nosocomial infections; as a result of their immunosuppressed systems (due to the treatments associated with illness); which in turn leads to prolonged stays, disability and economic burden [2,3]. Therefore, the search for novel compounds that displayed a broad range of therapeutic activities that can address these major health problems is of outmost importance [4]. New therapeutic drugs that contain a heterocyclic core are on the forefront of pharmaceutical research [5,6]. Pyrazoles, (1,2-azoles) have proven to be a remarkable scaffold for the synthesis of biologically active compounds [7-9] thanks to their wide range of medical applications that center mainly on antimicrobial [10-12] , antifungal [8,12,13] , antiinflammatory [7] , analgesic, and anxiolytic activities [13,14]. Some pyrazole derivatives have also shown antitumor activities towards several cancer cell lines, including leukemia (K562), HeLa cervix adenocarcinoma and Fem-x melanoma [14]. Consequently, in recent years pyrazole-base compounds have become a target of great interest.

Anti‐hepatocellular carcinoma, antioxidant, anti‐inflammation and antimicrobial investigation of some novel first and second transition metal complexes

“…So, chemists focus on the generation of new chemotherapeutic drugs. Schiff base derived from a heterocyclic ring with carbonyl compounds is one of the important special center of attraction in many biological, clinical, medicinal and pharmacological field . 4‐Aminoantipyrine based heterocyclic had a great importance as it is abundant in nature and several derivatives of antipyrine have a wide activity as analgesic, anti‐inflammatory, antimicrobial, and anticancer activity .…”

Antibacterial nanocomposite of chitosan/silver nanocrystals/graphene oxide (ChAgG) development for its potential use in bioactive wound dressings

“…ChAgG sample powder was dissolved in 0.1% dimethyl sulfoxide (DMSO) solvent at a concentration of 10 mg/mL. The antimicrobial activity test was performed using the serial dilution method 19 and carried out by inoculating the pathogenic strains Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 25923), previously incubated for 24 h at 35 °C in Mueller–Hinton medium (MHB at 23 g/L) in a 96 microwell plate, where the inoculated medium was placed, adding the sample at a concentration of 10 mg/mL in 0.1% DMSO solvent.…”

Synthesis, Characterization and Antimicrobial Activity of Novel Fused Tetracycline Pyrazolo[3,4-b]Pyridines

“…The nitrogen containing heterocycles are very important class of compounds in medicinal chemistry (1)(2)(3). Among them the pyrazole in different compounds shows diversified applications in different areas like technical, medical and agricultural field.…”