Anti‐hepatocellular carcinoma, antioxidant, anti‐inflammation and antimicrobial investigation of some novel first and second transition metal complexes

Abstract

New coordination compounds of some selected metal ions from the first and second transition metals series with a Schiff base were synthesized and characterized. The Schiff base is derived from 4‐Aminoantipyrine and 3‐(hydroxyimino) butan‐2‐one. The compounds were characterized by different analysis tools like; elemental analysis, mass spectra, Fourier transform infrared (FTIR) as well as electronic spectra, magnetic measurements, molar conductance and thermal analysis technique. All complexes were formed with 1:1 (metal: ligand) stoichiometry except Mn (II) where 1:2 (Mn: ligand) is formed. Schiff base ligand interacted as a tridentate ligand by using the nitrogen atoms of the imine and the oximato groups and the carbonyl oxygen atom as donor groups with all studied metal ions except copper (II) and manganese (II) where the carbonyl oxygen is not shared in the coordination. These complexes show various physicochemical properties. X‐ray powder diffraction shows different crystal systems; Cd (II) complex: hexagonal, Cu (II) complex: orthorhombic; and [Ni (II), Mn (II), Rh (III) & Pd (II)] complexes: monoclinic. All compounds showed potent cytotoxicity against the growth of human liver cancer cell lines. The square planar Pd (II) complex was more active than those of octahedral geometries of all other synthesized complexes. Cd (II) complex has the highest microbial growth inhibition than the rest of the prepared complexes. The docking active sites interactions were evaluated using the selected proteins EGFR tyrosine kinase and protein crystal structure of GlcN‐O‐P synthase. in vitro antioxidant assay revealed potent free radical scavenging activity of the three synthesized Cu (II), Pd (II) and Rh (III) complexes that exceeded the standard ascorbic acid. Pd (II) complex shows the most significant inhibition denaturation percent.

Synthesis, characterization, and density functional theory studies of hydrazone–oxime ligand derived from 2,4,6‐trichlorophenyl hydrazine and its metal complexes searching for new antimicrobial drugs

“…These atoms have more electronegative charge assuring active sites for chelation. (iii) The estimated dipole moment value of the ligand (H 2 L) is 0.9668 while the calculated dipole moment values for complexes (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) are in the 6.03-21.97 Debye range: the comparison of the estimated values of the dipole moments for the ligand and complexes (2-12) indicating that dipole moment for these complexes are higher than the dipole moment for the free ligand. This may be due the chelation of metal ions with the ligand took place via nitrogen atoms of azomethine and oximato groups.…”

“…4 T 1 (P)(v 3 ) are expected. [63,66,67] The EAS of Co 2+ complex (5) offered three peaks at 520, 700, and 1,090, which are ascribed to 4…”

“…The μ eff value of Mn 2+ and Fe 3+ complexes (3-4) are equal to 5.88 and 5.58 BM, signifying to five unpaired electrons systems and wellmatched with high-spin octahedral Mn 2+ and Fe 3+ ions. [65] The 4 F ground state of Co 2+ in a sphere of tetrahedral symmetry is split into 4 A 2 , 4 T 2 and 4 T 1 (F) and three spin-allowed transitions 4…”

“…Recently, compounds containing hydrazone and/or oxime linkage attracted the attention of many scholars because of their ability to form stable complexes with various transition metals, in addition to the presence of N-OH moiety, which could be enhance their chelation ability and make it more flexible in the reduction, oxidation, and conjugation with organic and inorganic compounds. These categories of compounds and their transition metal complexes showed biochemical [1] and bioactivity against pathogens resistant as antimicrobial, [2][3][4][5][6][7] antitumor, [3,4,8] anticancer, [9] anticandidal, [10] antitubercular, [11] antioxidant, and [4,12] anti-inflammatory analgesic [4,13] activities. Abdel-Aziz et al showed that the isoindoline-1,3-dione-based oximes and benzene-sulphonamide hydrazones have a selective inhibition of the tumor-associated carbonic anhydrase IX.…”

A hexanuclear Nd (III) complex derived from a Schiff base with significant antitumor and antifungal activity

“…Schiff base ligands continue to occupy an important position in metal coordination chemistry, especially transition metal complexes, ranging from pure synthetic work to modern physicochemical and biochemically relevant studies. [12][13][14][15][16][17][18][19][20][21] The lanthanide cations can promote Schiff base condensation and can give access to complexes of otherwise inaccessible ligands. Currently, Gd (III) complexes (Magnevist® and Artirem®) are commonly used as magnetic resonance imaging (MRI) contrast agents for cancer imaging, while Lu (III) complexes have been used in cancer imaging and therapy.…”