Fractional CO2 laser could be considered as a good way for hypertrophic scar management. It normalizes dermal collagen as imaged by histopathological picture and the change in TGF-β1 expression.

New coordination compounds of some selected metal ions from the first and second transition metals series with a Schiff base were synthesized and characterized. The Schiff base is derived from 4‐Aminoantipyrine and 3‐(hydroxyimino) butan‐2‐one. The compounds were characterized by different analysis tools like; elemental analysis, mass spectra, Fourier transform infrared (FTIR) as well as electronic spectra, magnetic measurements, molar conductance and thermal analysis technique. All complexes were formed with 1:1 (metal: ligand) stoichiometry except Mn (II) where 1:2 (Mn: ligand) is formed. Schiff base ligand interacted as a tridentate ligand by using the nitrogen atoms of the imine and the oximato groups and the carbonyl oxygen atom as donor groups with all studied metal ions except copper (II) and manganese (II) where the carbonyl oxygen is not shared in the coordination. These complexes show various physicochemical properties. X‐ray powder diffraction shows different crystal systems; Cd (II) complex: hexagonal, Cu (II) complex: orthorhombic; and [Ni (II), Mn (II), Rh (III) & Pd (II)] complexes: monoclinic. All compounds showed potent cytotoxicity against the growth of human liver cancer cell lines. The square planar Pd (II) complex was more active than those of octahedral geometries of all other synthesized complexes. Cd (II) complex has the highest microbial growth inhibition than the rest of the prepared complexes. The docking active sites interactions were evaluated using the selected proteins EGFR tyrosine kinase and protein crystal structure of GlcN‐O‐P synthase. in vitro antioxidant assay revealed potent free radical scavenging activity of the three synthesized Cu (II), Pd (II) and Rh (III) complexes that exceeded the standard ascorbic acid. Pd (II) complex shows the most significant inhibition denaturation percent.

New Pb(II), Mn(II), Hg(II), and Zn(II) complexes, derived from 4-(4-chlorophenyl)-1-(2-(phenylamino)acetyl)thiosemicarbazone, were synthesized. The compounds with general formulas, [Pb(H2L)2(OAc)2]ETOH.H2O, [Mn(H2L)(HL)]Cl, [Hg2(H2L)(OH)SO4], and [Zn(H2L)(HL)]Cl, were characterized by physicochemical and theoretical studies. X-ray diffraction studies showed a decrease in the crystalline size of compounds that were exposed to gamma irradiation (γ-irradiation). Thermal studies of the synthesized complexes showed thermal stability of the Mn(II) and Pb(II) complexes after γ-irradiation compared to those before γ–irradiation, while no changes in the Zn(II) and Hg(II) complexes were observed. The optimized geometric structures of the ligand and metal complexes are discussed regarding density functional theory calculations (DFT). The antimicrobial activities of the ligand and metal complexes against several bacterial and fungal stains were screened before and after irradiation. The Hg(II) complex has shown excellent antibacterial activity before and after γ-irradiation. In vitro cytotoxicity screening of the ligand and the Mn(II) and Zn(II) complexes before and after γ-irradiation disclosed that both the ligand and Mn(II) complex exhibited higher activity against human liver (Hep-G2) than Zn(II). Molecular docking was performed on the active site of MK-2 and showed good results.

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A self-assembly Pd-Schiff base complex was synthesized and used as an electrochemical sensor in phosphate buffer solution, where it enhanced the electrocatalytic activity toward the paracetamol detection. The Schiff base {(HL) = (4-(((Z)-3-(hydroxyimino) butan-2-ylidene) amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one)} was selected to prepare Pd-based complexes due to its high antimicrobial activity. A linear calibration curve was constructed using GC/Pd-SB in paracetamol concentration range of 1–50 μM and its detection limit was calculated as 0.067 μM. The modified electrode, GC/Pd-SB, could successfully determine the paracetamol concentration in human blood serum and commercial drug tablets with high sensitivity. The prepared metal complex was characterized using techniques, namely, X-ray diffraction (XRD) and scanning electron microscope (SEM). In addition, electrochemical studies were performed using different electrochemical techniques like cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry (CA), and electrochemical impedance spectroscopy (EIS). DFT calculations were used to estimate the equilibrium geometry, molecular orbital, ground-state properties, and interaction energy between paracetamol and palladium. Graphical Abstract

Coumarinyl thiosemicarbazone derivatives (1E)‐1‐(1‐(2‐oxo‐2H‐chromen‐3‐yl)ethylidene)thiosemicarbazide (OCET), (1E)‐1‐(1‐(6‐bromo‐2‐ oxo‐2H‐chromen‐3‐yl)ethylidene)thiosemicarbazide (BOCET) and 1‐(1‐(3‐oxo‐3H‐benzo[f]chromen‐2‐yl)ethylidene)thiosemicarbazide (NOCET) and their Rh(III) complexes were synthesized, the characterization was carried out by elemental analysis, IR, UV–Visible, mass, magnetic measurement and molar conductance techniques. Data interpretation of the Rh(III) complexes indicates that the ligands of coumarinyl thiosemicarbazone derivatives were formed in stoichiometric ratios as 1:2 (metal: ligand). The studied ligands act as a bidentate ligand by using both azomethine nitrogen and thiol sulphur as monoanion center of donation. The theoretical conformational structure analyses were performed using density functional theory for ligands and complexes at B3LYP functional with 6‐31G(++)d,p basis set for ligands and LANL2DZ basis set for complexes. The charge distribution within the ligands and its Rh(III) complexes was calculated using Mulliken population analysis of (MPA) and natural population analysis (NPA). The antibacterial activity of the prepared compounds was tested against some types of Gram positive and negative bacteria. Molecular docking investigation proved that, the ligands and complexes had interesting interactions with active site amino acids of ribosyltransferase (code: 3GEY).

The role of starch aerogel (St‐AG) and carboxymethyl cellulose (CMC) as biolgical active compounds, when they subjected for complexation with metal ions, is assessed in this work. The complexation is carried out with palladium(II) and copper(II) ions, in solid state. Different tools of analysis are carried out to characterize and elucidate the structures of these complexes, namely: elemental analysis, IR, thermal analysis, magnetic measurement and molar conductance techniques. All synthesized complexes are formed with 1:2 (metal:ligand) stoichiometry except the case of aerogel starch 1:1 (Pd:starch). All isolated complexes show a satisfactory cytotoxic effect results against colon cancer cell lines HCT11. Additionally, these complexes are screened for their antibacterial activities against two types of Gram positive and negative bacteria. Molecular docking investigation confirmed the cytotoxicity and antibacterial results. Proton–ligands association constants and their complex formation constants with some bivalent metal ions, using potentiometric method show that the complexes formed in solution have a stoichiometry of 1:1 [metal:ligand]. The effects of metal ion, ionic radius, electronegativity and nature of ligand on the formation constants are discussed. The formation constants of the complexes with 3D transition metals followed the order Mn2+ < Co2+ < Ni2+ < Cu2+ > Zn2+.

Pd(DME)Cl 2 complex was synthesized and characterized, where DME is 2-{[2-(dimethylamino)ethyl]-methylamino}ethanol. Stoichiometry and stability constants of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents, and dicarboxylic acids) and [Pd(DME)(H 2 O) 2 ] 2+ are investigated at 25 • C and at constant 0.1 M ionic strength. The effect of dielectric constant of the medium on the stability constant of Pd(DME)-CBDCA complex, where CBDCA is cyclobutanedicarboxylate, is also reported. The concentration distribution diagrams of the various species formed are evaluated. The kinetics of base hydrolysis of amino acid esters coordinated to Pd(DME) 2+ complex is investigated. The effect of the temperature on the kinetics of base hydrolysis of glycine methyl ester complex is studied. C 2010 Wiley Periodicals, Inc. Int J Chem Kinet 42: [608][609][610][611][612][613][614][615][616][617][618] 2010