Synthesis, Characterization and Antimicrobial Activity of Novel Fused Tetracycline Pyrazolo[3,4-b]Pyridines

Abstract

The nitrogen containing heterocycles are very important class of compounds in antileishmanial drug discovery. (1,2) Among them the pyrazole in different compounds shows diversified applications in different areas like technical, medical and agriculture field. They shows different pharmaceutical activity like antibacterial, antifungal, anticancer, antidepressant, antiinflammatory, anti- tuberculosis, antioxidant as well as antiviral agents (3,4). The fused derivatives of Pyrazole with another heterocyclic compounds studies for various pharmaceutical as well as biological activities (5,6). Pyrazolo [3,4-b] pyridine exhibit a broad variety of biological activities, like antimicrobial, insecticidal, anti- inflammatory, antineoplastic, anticonvulsant, antiparasitic, anti- fungal activities (7,8). Thus in continuous of our previous research work, it was thought to synthesised this type of fuse molecules. The present communication deals with the synthetic approach shown in scheme-1