Biological Activities of Solvent Extracts from Leaves of Aceriphyllum rossii

Abstract

In this study, the bioactivities of ethanol (EEAR) and water extract (WEAR) from the leaf of Aceriphyllum rossii were investigated. In the anti-oxidative activity, IC50 of DPPH radical scavenging activity was respectively 549.86 and 62.14 μg/mL by EEAR and WEAR. Anti-inflammatory activity of EEAR and WEAR has been evaluated on inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) release by the macrophage RAW 264.7 cells. EEAR and WEAR inhibited inflammatory by 5.58 and 16.85% in 10 mg/mL, respectively. In the anti-diabetic activity, IC50 of α-glucosidase inhibitory activity was 5.62 and 425.63 μg/mL by EEAR and WEAR. IC50 of α-amylase inhibitory activity of EEAR and WEAR was 4,623.87 and over 10,000 μg/mL, respectively. In the anti-obesity, all lipase inhibitory activity (IC50) of EEAR and WEAR was up 10,000 μg/mL. Finally, EEAR and WEAR exhibited anti-oxidative and anti-diabetic activity. It suggests that Aceriphyllum rossii could be potentially used as a resource of bioactive materials for health functional foods.

Antioxidant Activity and Anti-wrinkle Effects of Aceriphyllum rossii Leaf Ethanol Extract

“…The total polyphenol and flavonoid contents of ARLEE were 578.6 and 206.3 mg/g, respectively. These values are higher than the values reported by Lim et al (307.6 and 119.0 mg/g, respectively) (13) and even higher than those for epigallocatechin gallate, a well-known antioxidant agent (435 and 180 mg/g, respectively) (24) . The electron-donating ability of ARLEE at 1,000 μg/mL was 88.7%.…”

“…The electron-donating ability of ARLEE at 1,000 μg/mL was 88.7%. Lim et al reported its IC50 value at 549.9 μg/mL (13) .…”

“…The main chemical constituents of A. rossii are pentacyclic triterpenoids (11) . In previous studies, anticarcinogenic (12) , antioxidant, anti-inflammatory, antiobestic, antidiabetic (13) , and antimicrobial (14) activities of A. rossii have been reported. However, its inhibitory efficacy on skin wrinkling has been poorly investigated.…”

Effect of Centella asiatica Extract on Anti-obesity Suppression via Inhibition of Adipogenesis-related Gene Expression in Preadipocyte

“…LAI is used as an important indicator to evaluate antiobesity effects and it reached 68.1% in this experiment, which was 3.1 times higher than the value obtained for the hot-water extract of Aceriphyllum rossii leaves (21.9%), indicating that C. asiatica extract obtained via ultrasound can be used as an excellent anti-obesity agent to inhibit triglyceride hydrolysis (Lim et al, 2010). According to Gam et al, the mechanism underlying the anti-obesity effect of peanut shell extracts is due to the presence of polyphenol acting as an enzyme inhibitor for lipase, which in turn inhibits triglyceride hydrolysis and absorption (Gam et al, 2021).…”