We investigated the biological activities of extracts from the flowers of Angelica gigas Nakai. The IC50 of the DPPH radical scavenging activity was 3,535 and 105.0 μg/mL in the water and ethanol extracts, respectively, whereas it was 12.7 μg/mL for ascorbic acid. The results showed that the total polyphenol content of the ethanol extracts (48.43±0.18 mg/g) was higher than that of the water extracts (39.03±0.69 mg/g). The flavonoid content of the ethanol extracts (67.02±4.38 mg/g) was higher than that of the water extracts (50.32±1.24 mg/g). The ethanol extract showed a 34.45% lower α-glucosidase inhibition activity than that for acarbose. The ethanol extract showed a 23.62% lower α-amylase inhibition activity compared with that for acarbose. The water extract showed 16.76% lower pancreatic lipase inhibition activity. Anti-cancer and anti-inflammatory activity was also lower. These results suggest that the flower of Angelica gigas Nakai may be useful as an anti-oxidative agent.
In this study, the bioactivities of ethanol (EEAR) and water extract (WEAR) from the leaf of Aceriphyllum rossii were investigated. In the anti-oxidative activity, IC50 of DPPH radical scavenging activity was respectively 549.86 and 62.14 μg/mL by EEAR and WEAR. Anti-inflammatory activity of EEAR and WEAR has been evaluated on inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) release by the macrophage RAW 264.7 cells. EEAR and WEAR inhibited inflammatory by 5.58 and 16.85% in 10 mg/mL, respectively. In the anti-diabetic activity, IC50 of α-glucosidase inhibitory activity was 5.62 and 425.63 μg/mL by EEAR and WEAR. IC50 of α-amylase inhibitory activity of EEAR and WEAR was 4,623.87 and over 10,000 μg/mL, respectively. In the anti-obesity, all lipase inhibitory activity (IC50) of EEAR and WEAR was up 10,000 μg/mL. Finally, EEAR and WEAR exhibited anti-oxidative and anti-diabetic activity. It suggests that Aceriphyllum rossii could be potentially used as a resource of bioactive materials for health functional foods.
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