Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

Abstract

Distinct morphological MgO nanoparticles (MgONPs) were synthesized using biomasses of Saussurea costus roots. The biomass of two varieties of Saussurea costus (Qustal hindi and Qustal bahri) were used in the green synthesis of MgONPs. The physical and chemical features of nanoparticles were confirmed by spectroscopic and microscopic techniques. The surface morphology of the obtained nanoparticles was detected at different magnifications by SEM and TEM microscopy and the size of nanoparticles were found to be 30 and 34 nm for Qustal hindi and Qustal bahri, respectively. The antimicrobial activity of the prepared MgONPs was screened against six pathogenic strains. The synthesized nanoparticles by Qustal bahri biomass exerted significant inhibition zones 15, 16, 18, 17, 14, and 10 mm against E. coli, P. aeruginosa, C. tropicalis and C. glabrata, S. aureus and B. subtilis as compared to those from Qustal hindi 12, 8 and 17 mm against B. subtilis, E. coli and C. tropicalis, respectively. MgONPs showed a potential cytotoxicity effect against MCF-7 breast cancer cell lines. Cellular investigations of MgONPs revealed that the prepared nanoparticles by Qustal bahri exhibited high cytotoxicity against MCF-7 cancer cell lines. IC 50 values in MCF-7 cells were found to be 67.3% and 52.1% for MgONPs of Saussurea costus biomasses, respectively. Also, the photocatalytic activity of MgONPs of each Saussurea costus variety was comparatively studied. They exhibited an enhanced photocatalytic degradation of methylene blue after UV irradiation for 1 h as 92% and 59% for those prepared by Qustal bahri and Qustal hindi, respectively. Outcome of results revealed that the biosynthesized MgONPs showed promising biomedical potentials.

Saussurea lappa plant rhizome extract-based zinc oxide nanoparticles: synthesis, characterization and its antibacterial, antifungal activities and cytotoxic studies against Chinese Hamster Ovary (CHO) cell lines

“…Best of our knowledge, Saussurea lappa plant extract used for the synthesis of the oxides of the Silver [ 66 ], Magnesium [ 67 ], and Selenium [ 68 ] but no literature available on a synthesis of ZnO-NPs. In the light of the above, herein reporting the preparation of ZnO nanoparticles from roots (rhizome) of Saussurea lappa plant methanol extract and its anti-bacterial, anti-fungal activities and cytotoxicity effect of ZnO nanoparticles against Chinese Hamster Ovary (CHO) cell lines.…”

Prospective of biosynthesized L.satiVum oil/PEG/Ag-MgO bionanocomposite film for its antibacterial and anticancer potential

“…The inhibitory concentrations (IC 50 ) calculated for AgNPs and polymeric bionanocomposite were 220.35 μg mL −1 and 135 μg mL −1 , respectively. The results illustrated the polymeric bionanocomposite induced more cell death than AgNPs due to the presence of magnesium oxide ions which are reported as a cytotoxic agent towards many cancer cell lines including MCF-7, HT 29, Hep2 cells ( Amina et al, 2020 , Saravanakumar and Wang, 2019 ). Furthermore, many studies have shown that the silver-doped nanoparticles can easily penetrate the cell membrane and induce the free radicals, production of ROS and trigger the damage of the nucleus ( Jayapriya et al, 2020 ).…”

Costunolide, a Sesquiterpene Lactone, Suppresses Skin Cancer via Induction of Apoptosis and Blockage of Cell Proliferation

“…Researches for the biological effects of phytocomplex could contribute to find out the bioactive single molecule studied [6,7]. Indeed, as previously reported, costunolidecontaining phytocomplexes showed cytotoxic properties in various cancer cell lines [8][9][10]. Costunolide is a sesquiterpene lactone first obtained from the costus (Saussurea lappa Clarke) root [11] and subsequently isolated from several species of plants, including Aucklandia lappa Decne [12], Laurus nobilis [13], Magnolia grandiflora [14], and Michelia floribunda [15].…”