Biodegradation behavior of various calcium phosphate materials in bone tissue

Klein, C. P. A. T.; Driessen, A. A.; Groot, K. de; Hooff, A. van den

doi:10.1002/jbm.820170505

Cited by 547 publications

(269 citation statements)

References 10 publications

Supporting

Mentioning

239

Contrasting

Unclassified

Order By: Relevance

“…Figure 7A also displays the results for the degradation behavior of β-TCP samples at the different L/P. It is interesting to note that, in spite of having a much higher solubility, with a solubility product of 28.9 (-log K PS ) [11], [58] and larger pore sizes (Fig. 6), its degradation was lower than that of CDHA, which can be explained by the much smaller SSA.…”

Section: Discussionmentioning

confidence: 99%

“…The former, i.e. Ca 9 (PO 4 ) 5 (HPO 4 )(OH), is inherently more soluble than stoichiometric HA, i.e.Ca 10 (PO 4 ) 6 (OH) 2 [57], with solubility products of 85.1 (-log K PS ) and 116.8 (-log K PS ) respectively [11], due to its distorted lattice and consequently lower crystallinity. The results obtained suggest that the incorporation of carbonate ions in this kind of pre-distorted lattice does not have the same effect than in stoichiometric HA; rather than increasing the solubility the opposite happens.…”

Section: Discussionmentioning

confidence: 99%

“…The bottleneck for most CaP formulations, including hydroxyapatite-based formulations, is their poor resorption rate, especially for sintered HA, which is one of the most commonly used materials [10]. In vivo studies have proved that even after 9 months of implantation sintered HA remained at the site with hardly any sign of resorption [11,12]. To circumvent this problem, HA has been combined with more soluble phases such as β-tricalcium phosphate (β-TCP) [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

View full text Add to dashboard Cite

Please cite this article as: Díez-Escudero, A., Espanol, M., Beats, S., Ginebra, M.P., In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

View full text Add to dashboard Cite

show abstract

“…122 On the basis of the composition and stoichiometry of a calcium-phosphate ceramic, important physical properties such as degradation rate, modulus, and processability can be changed. [123][124][125][126] Research on TCP materials has revealed that the degradation rate is too rapid in vivo, while synthetic versions of HAp degrade too slowly to allow native tissue integration. This phenomenon motivated the development of BCP and bio-glasses which have tunable (to some degree) degradation rates based on the relative magnitude of TCP (more commonly b-TCP) and HAp in a composite ceramic.…”

Section: Bone Biomimeticsmentioning

confidence: 99%

“…rate. 123,129,130,140,147 However, these materials hold little clinical utility due to their poor mechanical properties discussed above. Natural polymers such as collagen, fibrin, alginate, gelatin, and GAGs have also been extensively investigated as drug delivery vehicles in bone tissue engineering.…”

Section: Localized Bioactive Molecule and Drug Delivery In Bone Repairmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

676

499

View full text Add to dashboard Cite

Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

show abstract

Differential effects of different forms of hydroxyapatite and hydroxyapatite/tricalcium phosphate particulates on human monocyte/macrophagesin vitro

Harada

Wang

Doppalapudi

et al. 1996

J. Biomed. Mater. Res.

100

View full text Add to dashboard Cite

A possible complication associated with the use of hydroxyapatite (HA) or HA/tricalcium phosphate (HA/TCP) coating on the surfaces of prosthetic devices used for dental and orthopedic implants is their potential to fragment and thus exist as wear debris. In contrast to the so-called osteoconductive properties of HA or HA/TCP coatings, in particulate form these materials may lead to an adverse pattern of cellular and tissue responses at the bone-implant interface. We have established an in vitro cell culture system to characterize the biologic and biochemical effects of various particulate materials. The present study demonstrates that the HA/TCP particles derived from different sintering temperatures exhibit differential effects on cultured human monocyte/macrophages (M/M). The HA/TCP particles dried at 110 degrees C were the most biologically active, stimulating significant release of interleukin 1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha, and prostaglandin E2 (PGE2), products implicated as important mediators of inflammation in diverse pathologic conditions. Other particles, sintered at either 900 or 1200 degrees C, did not stimulate production of cytokines or PGE2. HA/TCP particles from plasma-spray coatings also failed to release proinflammatory products. These results suggest that the biochemical and crystalline structural properties of particles markedly affects their capacity to modulate M/M function. This in vitro culture system should be useful in characterizing the specific physical and chemical properties of HA or HA/TCP particulates that are responsible for stimulating proinflammatory cell responses.

show abstract

Biodegradation behavior of various calcium phosphate materials in bone tissue

Cited by 547 publications

References 10 publications

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Differential effects of different forms of hydroxyapatite and hydroxyapatite/tricalcium phosphate particulates on human monocyte/macrophagesin vitro

Contact Info

Product

Resources

About