Biocompatible, hyaluronic acid modified silicone elastomers

Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid – Collagen conjugate for neural interfacing

“…Enhanced surface hydrophilicity has been demonstrated previously by modification of PDMS with hydrophilic polymers such as poly(ethylene glycol) derivatives [29,30], poly(2-hydroxyethyl methacrylate) [31], 2-methacryloylethyl phosphorylcholine polymer [20] or copolymer [32], and poly(ethylene-alt-maleic anhydride) [22]. These studies reported various levels of hydrophobicity recovery upon storage in air.…”

Competitive protein adsorption on polysaccharide and hyaluronate modified surfaces

“…Patterned surfaces of dextran and HA show preferential attachment of macrophages to the dextranized regions (Tsai et al 2011b). In contrast to cell binding resistance, some HA materials have been shown to enhance bacterial adhesion, and HA modified PDMS surfaces were recently shown to enhance corneal epithelial cell and 3T3 fibroblast adhesion (Alauzun et al 2010). These examples indicate that resistance to, or enhancement of, adhesion of specific cell lines may depend on the presence of HA molecules in the surface layer.…”

Physical Entrapment of Hyaluronic Acid During Synthesis Results in Extended Release From Model Hydrogel and Silicone Hydrogel Contact Lens Materials

“…[2][3][4][5] Hyaluronic acid has been shown to be nontoxic, 6 able to support cell growth, 7 and can encourage angiogenesis. [2][3][4][5] Hyaluronic acid has been shown to be nontoxic, 6 able to support cell growth, 7 and can encourage angiogenesis.…”