Physical Entrapment of Hyaluronic Acid During Synthesis Results in Extended Release From Model Hydrogel and Silicone Hydrogel Contact Lens Materials

Weeks, Andrea; Subbaraman, Lakshman N.; Jones, Lyndon; Sheardown, Heather

doi:10.1097/icl.0b013e318281ae06

Cited by 23 publications

(21 citation statements)

References 49 publications

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“…Hyaluronic acid (HA), a hydrophilic glycosaminoglycan found throughout the human body, has been used in contact lens rewetting drops and in a range of artificial tear products to treat mild, moderate, and severe dry eye, 155,156 and has been used as a novel internal wetting agent for contact lens materials. [157][158][159][160][161][162] However, to our knowledge, HA has not been shown in any clinical studies to directly improve comfort associated with contact lens wear.…”

Section: Wetting Agent Incorporationmentioning

confidence: 99%

The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Materials, Design, and Care Subcommittee

Jones

Brennan

González-Meijóme

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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186

167

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Contact Lens Materials Given the fact that approximately 90% of the world's contact lens wearers are wearing soft lenses with no recent change in this figure, 1 this report primarily concerns itself with the role of soft lens materials and designs and care solutions in CLD, with some discussion of rigid gas permeable lens (RGP) materials or designs where appropriate. Conventional Hydrogel Materials The pioneering work of Wichterle and colleagues 2,3 is well known as a basis for the development of hydrogel polymers for soft contact lenses, including lightly cross-linked polymers of 2

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Section: Wetting Agent Incorporationmentioning

confidence: 99%

The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Materials, Design, and Care Subcommittee

Jones

Brennan

González-Meijóme

et al. 2013

Invest. Ophthalmol. Vis. Sci.

Self Cite

186

167

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“…In these experiments, it was also shown that the released hyaluronic acid induced a decrease in lysozyme sorption of contact lenses. 28 Eye & Contact Lens Volume 0, Number 0, Month 2015 Dry Eye Treatment by Contact Lens Drug Delivery…”

Section: Rewetting or Comfort Agentsmentioning

confidence: 99%

“…27 Additionally, hyaluronic acid has been physically incorporated into the conventional and silicone hydrogel contact lens material during contact lens synthesis. 28 Hyaluronic acid could be released from p-HEMA hydrogels for at least 21 days and from the silicone hydrogels for an extended period of up to 7 weeks. In these experiments, it was also shown that the released hyaluronic acid induced a decrease in lysozyme sorption of contact lenses.…”

Section: Rewetting or Comfort Agentsmentioning

confidence: 99%

Dry Eye Treatment Based on Contact Lens Drug Delivery: A Review

Guzmán-Aránguez

Fonseca

Carracedo

et al. 2016

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Dry eye disease affects a substantial segment of the word population with increasing frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular discomfort, visual disturbances, and tear instability with potential damage to the cornea and conjunctiva. Because of its multifactorial etiology, the use of different pharmacological treatment for dry eye treatment has been proposed, which include anti-inflammatory molecules, lubricants or comfort agents, and secretagogues. However, in some cases these pharmacological approaches only relieve symptoms temporarily, and consequently, eye care professionals continue to have difficulties managing dry eye. To improve pharmacological therapy that allows a more efficient and long-term action, effective ocular drug delivery of the currently available drugs for dry eye treatment is required. Contact lenses are emerging as alternative ophthalmic drugs delivery systems that provide an increased residence time of the drug at the eye, thus leading to enhanced bioavailability and more convenient and efficacious therapy. In this article, we reviewed the different techniques used to prepare contact lens-based drug delivery systems and focused on articles that describe the delivery of compounds for dry eye treatment through contact lenses.

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“…Recently, Van Beek and Andrea Weeks co-workers reported hyaluronic acid (HA) containing silicone hydrogels and poly (2-HEMA) gels with HA immobilized as a wetting agent. [15,16] HA has been widely studied since last 20 years as an ophthalmic comfort enhancing agent. [17][18][19] It has been shown to promote water retentive properties and its viscoelasticity provides tear fluid stability in dry eyes.…”

Section: Introductionmentioning

confidence: 99%

Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome

Maulvi

Soni

Shah

2015

Journal of Biomaterials Science, Polymer Edition

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Current dry eye treatment includes delivering comfort enhancing agents to the eye via eye drops, but low residence time of eye drops leads to low bioavailability. Frequent administration leads to incompliance in patients, so there is a great need for medical device such as contact lenses to treat dry eye. Studies in the past have demonstrated the efficacy of hyaluronic acid (HA) in the treatment of dry eyes using eye drops. In this paper, we present two methods to load HA in hydrogel contact lenses, soaking method and direct entrapment. The contact lenses were characterized by studying their optical and physical properties to determine their suitability as extended wear contact lenses. HA-laden hydrogel contact lenses prepared by soaking method showed release up to 48 h with acceptable physical and optical properties. Hydrogel contact lenses prepared by direct entrapment method showed significant sustained release in comparison to soaking method. HA entrapped in hydrogels resulted in reduction in % transmittance, sodium ion permeability and surface contact angle, while increase in % swelling. The impact on each of these properties was proportional to HA loading. The batch with 200-μg HA loading showed all acceptable values (parameters) for contact lens use. Results of cytotoxicity study indicated the safety of hydrogel contact lenses. In vivo pharmacokinetics studies in rabbit tear fluid showed dramatic increase in HA mean residence time and area under the curve with lenses in comparison to eye drop treatment. The study demonstrates the promising potential of delivering HA through contact lenses for the treatment of dry eye syndrome.

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Physical Entrapment of Hyaluronic Acid During Synthesis Results in Extended Release From Model Hydrogel and Silicone Hydrogel Contact Lens Materials

Cited by 23 publications

References 49 publications

The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Materials, Design, and Care Subcommittee

The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Materials, Design, and Care Subcommittee

Dry Eye Treatment Based on Contact Lens Drug Delivery: A Review

Extended release of hyaluronic acid from hydrogel contact lenses for dry eye syndrome

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