The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Materials, Design, and Care Subcommittee

Abstract

Contact Lens Materials Given the fact that approximately 90% of the world's contact lens wearers are wearing soft lenses with no recent change in this figure, 1 this report primarily concerns itself with the role of soft lens materials and designs and care solutions in CLD, with some discussion of rigid gas permeable lens (RGP) materials or designs where appropriate. Conventional Hydrogel Materials The pioneering work of Wichterle and colleagues 2,3 is well known as a basis for the development of hydrogel polymers for soft contact lenses, including lightly cross-linked polymers of 2

In vitro friction testing of contact lenses and human ocular tissues: Effect of proteoglycan 4 (PRG4)

“…The Tear Film & Ocular Surface Society's recent report of the impact of contact materials, design and solutions on contact lens discomfort [8] reported that friction is currently the only material variable to correlate well with in vivo comfort scores, based upon data from two studies [9,10]. This work strongly suggests that superior frictional properties of lens materials are a key parameter that significantly correlates to contact lens comfort.…”

Fluorescent solute-partitioning characterization of layered soft contact lenses

“…Partitioning of packaging, wetting, and care-solution agents in soft contact lenses (SCLs) is a well-explored avenue for improving and maintaining on-eye lens performance [1][2][3][4][5][6]. Similarly, partitioning of tear components in SCLs, such as proteins, salts and lipids, can affect lens behavior during wear [1,[7][8][9][10][11].…”

“…Similarly, partitioning of tear components in SCLs, such as proteins, salts and lipids, can affect lens behavior during wear [1,[7][8][9][10][11]. Further, solute partitioning is critical for possible use of SCLs as a drug-delivery vehicle [12][13][14][15].…”

Lid Margin Sensitivity and Staining in Contact Lens Wear Versus No Lens Wear

“…1,2 CLD is characterized by a series of adverse sensations related to lens wear that may lead to decreased comfortable wearing hours, a reduction in total wearing time and discontinuation from lens wear. 3 Many factors have been related to CLD, such as lens modulus, surface properties, design and fit, care system, 4 tear film characteristics, 5 and contact lens-related pathology such as giant papillary conjunctivitis. 6 Comprehensive recent reviews of this area have been provided by the TFOS International Workshop on Contact Lens Discomfort 7 and Chalmers.…”