Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

Wu, Huixia; Liu, Gang; Zhang, Shengjian; Shi, Jianlin; Zhang, Lingxia; Chen, Yu; Chen, Feng; Chen, Hangrong

doi:10.1039/c0jm02863k

Cited by 169 publications

(109 citation statements)

References 49 publications

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“…Radionuclides which emit gamma rays are used in SPECT and a gamma camera rotates 360 degrees around the patient to obtain several images from different positions. Radionuclides typically employed for SPECT include 67 Ga, 99 Tm, 111 In, and 123 I having long half lives of 3.3 days, 6 hours, 2.8 days, and 13.1 hours respectively. PET employs radionuclides which undergo decay by emitting positrons which interact with electrons in the body to produce a pair of annihilation photons which are detected.…”

Section: Radionuclide Imaging (Ri)mentioning

confidence: 99%

The Upcoming Field of Theranostic Nanomedicine: An Overview

Prabhu

Patravale²

2012

Journal of Biomedical Nanotechnology

127

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Nanocarriers have drastically changed the face of health care by making a mark in diverse arenas of diagnosis, drug delivery, and gene delivery to name a few. The recent feat in nanotechnology has been the birth of nanotheranostics which aims at blending both therapeutic and diagnostic functions within a single nanoscaffold. The field of theranostic nanomedicine is a result of fruitful advances in fields of material science, imaging modalities, formulation development, and molecular biology. Theranostic nanomedicine that was at first developed for enhancing the quality of treatment meted out to cancer patients has now been explored even in atherosclerosis and infections, albeit to a lower extent. The review summarizes various types of nanocarriers that have been explored with one or sometimes multiple imaging modalities for an array of applications ranging from drug delivery and gene delivery to photosensitizing agent delivery for photodynamic therapy. The article also highlights the few but significant developments made in the field of theranostic nanomedicine for atherosclerosis and infections. In conclusion, theranostic nanomedicine is a rapidly growing field. However, there are a few problems that need to be addressed before theranostic nanocarriers carve a niche for themselves in the clinic.

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Section: Radionuclide Imaging (Ri)mentioning

confidence: 99%

The Upcoming Field of Theranostic Nanomedicine: An Overview

Prabhu

Patravale²

2012

Journal of Biomedical Nanotechnology

127

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“…The control mice were injected with 300 µL 1 mg mL −1 MSNCs, 300 µL 1 mg mL −1 DOX@ PEGylated-MSNC, [ 32 ] 300 µL PBS (pH = 7.4), and 300 µL 1 mg mL −1 free DOX solution, respectively. The control mice were injected with 300 µL 1 mg mL −1 MSNCs, 300 µL 1 mg mL −1 DOX@ PEGylated-MSNC, [ 32 ] 300 µL PBS (pH = 7.4), and 300 µL 1 mg mL −1 free DOX solution, respectively.…”

Section: Drug Delivery In Vivo and Evaluation Of Tumor Inhibitedmentioning

confidence: 99%

Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy

Xuan

Shao

Dai

et al. 2015

Adv Healthcare Materials

275

216

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“…Furthermore, the Fe 3 O 4 /FMSMs carriers could deliver DOX into the cell cytoplasm and cell nucleus [19] . Shi and coworkers [20–22] reported a series of Fe 3 O 4 /Fe 2 O 3 @mSiO 2 nanocapsules with a single or double mesoporous silica shell, and these nanocapsules had sufficient magnetic responsivity and high anticancer drug loading capacity [20], [21], [22] . Also, the DOX-loaded nanocapsules showed greater cytotoxicity to induce MCF-7 cell death than free DOX.…”

Section: Introductionmentioning

confidence: 99%

Preparation of magnetic mesoporous silica nanoparticles as a multifunctional platform for potential drug delivery and hyperthermia

Xia

Zhu

2016

Science and Technology of Advanced Materials

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We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2), and the rattle-type structured MMS nanoparticles (MCN/mSiO2) were obtained after the removal of the carbon layers from MCN@C/mSiO2 nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior, in vitro cytotoxicity and cellular uptake of MMS nanoparticles were investigated. The results revealed that the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles had spherical morphology and average particle sizes of 390 and 320 nm, respectively. The MCN@C/mSiO2 nanoparticles exhibited higher magnetic hyperthermia ability compared to the MCN/mSiO2 nanoparticles, but the MCN/mSiO2 nanoparticles had higher drug loading capacity. Both MCN@C/mSiO2 and MCN/mSiO2 nanoparticles had similar drug release behavior with pH-controlled release and temperature-accelerated release. Furthermore, the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles showed low cytotoxicity and could be internalized into HeLa cells. Therefore, the MCN@C/mSiO2 and MCN/mSiO2 nanoparticles would be promising for the combination of drug delivery and magnetic hyperthermia treatment in cancer therapy.

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Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands

Cited by 169 publications

References 49 publications

The Upcoming Field of Theranostic Nanomedicine: An Overview

The Upcoming Field of Theranostic Nanomedicine: An Overview

Macrophage Cell Membrane Camouflaged Mesoporous Silica Nanocapsules for In Vivo Cancer Therapy

Preparation of magnetic mesoporous silica nanoparticles as a multifunctional platform for potential drug delivery and hyperthermia

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