Engineering natural macrophage cell membrane-camouflaged mesoporous silica nanocapsules can reduce the arrested percentage of immune cells and tissues, effectively prolong the survival time of nanoparticles in blood circulation system, and improve the accumulation in tumor.

On page 1645 Q. He, J. Li and colleagues present natural macrophage cell membrane camouflaged silica nanocapsules through a top‐down assembly. The employed cell membrane coating can effectively weaken immune response in biological entity, and achieve longer survival time and higher accumulation in the tumor. This strategy supplies a high‐efficiency delivery platform for in vivo transportation such as drugs and imaging probes.