Biocompatibility, antioxidant activity and collagen photoprotection properties of C60 fullerene adduct with L-methionine

Sharoyko, Vladimir V.; Shemchuk, Olga S.; Meshcheriakov, Anatolii A.; Vasina, Lubov V.; Iamalova, Nailia R.; Luttsev, Michail D.; Ivanova, Daria A.; Petrov, Andrey V.; Maystrenko, D. N.; Molchanov, Oleg Е.; Semenov, Konstantin N.

doi:10.1016/j.nano.2021.102500

Cited by 20 publications

(15 citation statements)

References 70 publications

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“…Polyhydroxylated fullerene (called fullerenol), produced by adding the OH groups to the carbon surface of fullerene, has greatly improved water-solubility and decreased cytotoxicity [ 2 ]. Fullerenol also shows outstanding characteristics including antioxidant activity, antiviral property and anti-inflammatory function in chemical and biological systems [ 3 , 4 ]. Moreover, some derivatives have the ability to reduce excitotoxicity and apoptosis after epileptic seizures, prevent functional disturbances in hippocampus, inhibit glioblastoma cell proliferation and improve neural regeneration [ 5 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo

et al. 2022

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Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its enormous potential in biomedical applications. However, the in vivo performance of fullerenol remains largely unclear. We aimed to investigate the effect of fullerenol (i.p., 5 mg/kg) on the impaired hippocampus in a rat model of lead exposure. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF–MS) is a kind of newly developed soft-ionization mass spectrometry technology. In the present study, an innovative strategy for biological distribution analysis using MALDI-TOF–MS confirmed that fullerenol could across the blood–brain barrier and accumulate in the brain. Results from behavioral tests showed that a low dose of fullerenol could improve the impaired learning and memory induced by lead. Furthermore, electrophysiology examinations indicated that this potential repair effect of fullerenol was mainly due to the long-term changes in hippocampal synaptic plasticity, with enhancement lasting for more than 2–3 h. In addition, morphological observations and biochemistry analyses manifested that the long-term change in synaptic efficacy was accompanied by some structural alteration in synaptic connection. Our study demonstrates the therapeutic feature of fullerenol will be beneficial to the discovery and development as a new drug and lays a solid foundation for further biomedical applications of nanomedicines.

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Section: Introductionmentioning

confidence: 99%

Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo

et al. 2022

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“…We might stress it out here that a particular advantage of this In Silico path would allow to avoid a routine post-experiment data description/treatment [8,9,11,12,21,20] due to computational prognostic power realized by an interative taking into account of known PMC16 pharmacology, 25 Mg -MIE mammalian tissue hypoxia and BBB functional parameters-including the stroke related peculiarities [13,20,22,24,28].…”

Section: Results and Its Discussionmentioning

confidence: 99%

“…Noteworthy, the cation -exchanging nanoparticles (PMC16 family members) we're taking here for granted as the "safe-n-stable" adducts of fullerene -C 60 are all known water soluble products with the marked antioxidant, i.e. potentially antihypoxia, properties for themselveseven once applied unloaded by any metal ions [10][11][12][13]. Thus, amphiphilic fullerenecontaining compounds are, most likely, capable to emphasize the magnetic isotope effects of 25 Mg 2+ on ATP-synthase and nucleotidyl kinases reaching both ATP hyperproduction and an oxygen consumption decrease [11,12] so beneficial for neuroprotection in the hypoxiadamaged brain tissue regions.…”

Section: Introductionmentioning

confidence: 99%

An Advanced in Silico Model to Optimize the Pharmacokinetic Studies ON25 Mg2+ – Releasing Porphyrin – Fullerene Nanoparticles in Brain Ischemic Disorders

Fursov

Namestnikova

Кузнецов

2022

Preprint

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The In Silico study on neuropharmacokinetiks of some novel porphyrin-fullerene based 25Mg2+ - nanocarriers was performed with an aim to optimize the preclinical research path required for both prevention and correction of the brain ischemic stroke related metabolic disorders such us ATP deplete and its direct consequences. Thus, the local brain tissue hypoxia scenario are in a focus of this novel analytical approach suitable for prediction of some parameters of the 25Mg – magnetic isotope effect promoted antihypoxic activities as long as they relates upon delivery, distribution and intralization of the low toxic/amphiphilic Mg2+ – releasing nanoparticles of PMC16 type. This is the first report ever on mathematical model applied to predict and to prove a mere phenomenon of the “cellular pump” keeping the constant traffic of PMC16 particles towards a brain hypoxia area even when/if lowest concentration of pharmacophore were the case. For experimental verifications of the In Silico platform proposed, a combination of (a) the rat brain occlusion – promoted ischemic stroke model and (b) the capillary zone electrophoretic (CZE) quantification of PMC16-RX nanoparticles in cytosol fractions isolated from intact / penumbra / stroke brain areas, has been employed.

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“…C60 molecules can interact with each other and with up to 34 methyl radicals. C60 can be used as an effective antioxidant and free radical scavenger for its electron donor and acceptor capability, and it does not possess any genotoxic effects on human lymphocytes or mutagenic effects in vivo and in vitro ( Hao et al., 2016 ; Aly et al., 2018 ; Vereshchaka et al., 2018 ; Sharoyko et al., 2021 ). These fullerene compounds include polyhydroxy C60 (fullerol), carboxylated fullerene, and polysulfonated C60, which have been proved to block the damage from free radicals in several diseases related to oxidative stress, such as ischemia/reperfusion injury, inflammatory cell apoptosis, and neurogenic diseases ( Zhou et al., 2010 ; Hao et al., 2016 ; Liao et al., 2021 ; Nozdrenko et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary zero-dimensional fullerene supplementation improves the meat quality, lipid metabolism, muscle fiber characteristics, and antioxidative status in finishing pigs

et al. 2022

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Biocompatibility, antioxidant activity and collagen photoprotection properties of C60 fullerene adduct with L-methionine

Cited by 20 publications

References 70 publications

Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo

Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo

An Advanced in Silico Model to Optimize the Pharmacokinetic Studies ON25 Mg2+ – Releasing Porphyrin – Fullerene Nanoparticles in Brain Ischemic Disorders

Dietary zero-dimensional fullerene supplementation improves the meat quality, lipid metabolism, muscle fiber characteristics, and antioxidative status in finishing pigs

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