Long-term maintenance of synaptic plasticity by Fullerenol Ameliorates lead-induced-impaired learning and memory in vivo

Abstract

Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its enormous potential in biomedical applications. However, the in vivo performance of fullerenol remains largely unclear. We aimed to investigate the effect of fullerenol (i.p., 5 mg/kg) on the impaired hippocampus in a rat model of lead exposure. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF–MS) is a kind of newly developed soft-ionization mass spectrometry technology. In the present study, an innovative strategy for biological distribution analysis using MALDI-TOF–MS confirmed that fullerenol could across the blood–brain barrier and accumulate in the brain. Results from behavioral tests showed that a low dose of fullerenol could improve the impaired learning and memory induced by lead. Furthermore, electrophysiology examinations indicated that this potential repair effect of fullerenol was mainly due to the long-term changes in hippocampal synaptic plasticity, with enhancement lasting for more than 2–3 h. In addition, morphological observations and biochemistry analyses manifested that the long-term change in synaptic efficacy was accompanied by some structural alteration in synaptic connection. Our study demonstrates the therapeutic feature of fullerenol will be beneficial to the discovery and development as a new drug and lays a solid foundation for further biomedical applications of nanomedicines.

Fullerenol inhibits tendinopathy by alleviating inflammation

“…Fullerenol is a hydroxylated derivative of fullerene. Identical to previous studies ( Wang et al, 2016 ) ( Zha et al, 2022 ), the diameter of our aqueous fullerenol ranged from 100 to 1,000 nm. Notably, fullerenol was also manufactured to be nanomaterial with diameter lower than 100 nm ( Chen et al, 2022 ).…”

Fullerenols Ameliorate Social Deficiency and Rescue Cognitive Dysfunction of BTBR T+Itpr3tf/J Autistic-Like Mice

“…19,20 As a nanocomposite with promising applications, fullerenols are less harmful to living organisms and can cross the blood-brain barrier. 21,22 Additionally, fullerenols have a range of abilities, including anti-human immunodeficiency virus, antioxidant, anti-inflammatory, and neuroprotective properties. [23][24][25][26][27][28][29][30] Recent studies have revealed that fullerenols can restore normal dopaminergic neuron levels in the brain and reduce α-synuclein aggregation, which suggests that it could be neuroprotective agent for Parkinson's disease.…”

Alleviation of Photoreceptor Degeneration Based on Fullerenols in rd1 Mice by Reversing Mitochondrial Dysfunction via Modulation of Mitochondrial DNA Transcription and Leakage

“…[ 9 ] Water‐soluble polyhydroxylated fullerene derivatives, namely fullerenols, have a diameter of ≈1 nm with symmetrically arranged hydroxyl groups on C 60 spheres. [ 10 ] Stability for real‐time applications and intracellular localization [ 11 ] by directly crossing the cellular membrane [ 12 ] are prerequisites for fullerenols used in biomedical applications. Electron‐deficient carbon─carbon double bonds and hydroxyl groups can quench numerous electrophilic radicals; [ 13 ] this remarkable reaction to free radicals is the most important property of fullerenols.…”