Biochemistry of Serum and Saliva in Obese Individuals with Periodontitis : Case - Control Study

Sarhat, Entedhar R.; Mohammed, Intesar J.; Hamad, Abdullah

doi:10.12816/0036366

Cited by 6 publications

(9 citation statements)

References 44 publications

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“…An agreement with many other studies who indicating a strong association between baseline CRP serum level and occurrence of DN [20,21]. In contrast with another study suggested there is no relation between CRP base line level and development of DN [22].Our study demonstrated the a significant positive relation between the CRP serum level and Urine Albumincreatinine ratio (UACR) in type tow diabetic patients which is consider as a marker for the development of DN this finding confirmed the involvement of CRP in development of DN an agreement with many previous studies who concluded the association of CRP and Urine albumin-creatinine ratio [23,24].This finding was consistent with a known mechanism of CRP as a strong proinflammatory agent that act to increase release of other inflammatory mediator as well as activate migration of macrophage and monocyte to the kidney which secret free radical and release of inflammatory gents these chemicals promote cells injury by amplifying inflammatory response. Also, CRP paly important role in mesenchymal cell proliferation by release of proinflammatory cytokines in addition to increase glomerular albumin permeability which finally lead to albuminuria [9].…”

Section: Discussionsupporting

confidence: 90%

Association of C-Reactive Protein with Risk of Complications of diabetic nephropathy

2021

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Background: Diabetic nephropathy become the main cause of chronic renal diseases in the world, that have been demonstrated high mortality rate and disability in patients with diabetes mellitus. Many recent studies demonstrate the associations of CRP and development of renal impairment in type two diabetic patients demonstrating the relation between systemic inflammation and glycemic control and consequently with severity of diabetic complications. Aim of study: evaluate the role of CRP and to analyze any correlation of CRP with nephropathy complications of diabetes. Material: the study was a cross sectional study of 62 type tow diabetic patients attended to Kirkuk general Hospital and 28 healthy subjects. Patient group was separated into two groups first include those have diabetic nephropathy and the second group include patient s without nephropathy. CRP level in serum sample was evaluated and albumin-creatinine ratio in random urine samples were calculated. Results: the present study revealed that the CRP serum concentration was significantly high in patient with nephropathy than those without nephropathy (P< 0.01). Also, demonstrated that the urine albumin-creatinine ratio was significantly increased in patients with nephropathy as compared with those without nephropathy as well as there is a strong positive correlation between CRP and urine albumin-creatinine ratio. Conclusion: A positive correlation of CRP with albumin-creatinine ration indicating the role of CRP in development of DN and possibility of used CRP measurement to predicate the DN development in type two diabetic patients. also supports the treatment targeting inflammatory mediators in improving diabetic complication.

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Section: Discussionsupporting

confidence: 90%

Association of C-Reactive Protein with Risk of Complications of diabetic nephropathy

2021

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“…Dental examination, clinical periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were assessed (6) , were conducted by well-trained dentist. Approximately 3ml of non-stimulated expectorated whole saliva was collected from each patient, into sterile tubes according to Navazesh method (7).…”

Section: Methodsmentioning

confidence: 99%

Changes of Salivary Interleukine-17, Apelin, Omentin and Vaspin Levels in Normal Subjects and Diabetic Patients with Chronic periodontitis

Sarhat¹,

Rmaid²,

Jabir³

2020

ATMPH

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Background: Chronic periodontitis is a chronic inflammatory disease which is multifactorial. Diabetes mellitus is one of the major systemic factors to influence the severity of chronic periodontitis. Therefore, the aim of current study was to assess salivary biomarkers of Interleukine-17(IL-17), apelin, omentin and vaspin as putative candidates in the potential association between Diabetes mellitus and Chronic periodontitis. Methods: Whole saliva samples were collected from sixty adults sex and agematched patients who were further divided into two groups; healthy (control group; n = 30) and diabetic individuals with chronic periodontitis (n = 30). Salivary IL-17, apelin, omentin andvaspin concentrations were determined by standard enzyme-linked immune-sorbent assay. Results: Salivary levels of IL-17, apelin and vaspin were significantly higher in diabetic patients with periodontitis group compared to control group. On the other hand, salivary levels of omentin were significantly lower in diabetic patients with periodontitis compared to control group. Conclusions: Our study supports the hypothesis that abnormal production of IL-17, apelin, omentin and vaspin can contribute to the pathogenesis of diabetes-related complications including Chronic periodontitis.

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“…Recent evidence indicates that PON-1 might play an essential role in the protection against the formation of bacterial biofilm. [20][21][22] An experimental study showed that a reduced level of PON-1 led to a decrease in HSL hydrolysis, which induced dental biofilm formation and periodontitis. 21 In addition, an in vitro study suggested that PON-1 played an important role in the osteoblastic differentiation of periodontal ligaments.…”

Section: Discussionmentioning

confidence: 99%

“…23 Several clinical studies showed that the acute-phase response induced by endotoxins and lipopolysaccharides, as well as an increased release of inflammatory cytokines can decrease PON-1 activity in serum. 22,24 Moreover, PON-1 has a protective function against atherosclerosis. 16 Preclinical studies showed that PON-1 inhibited the oxidation of low-density lipoprotein (LDL).…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase-1, a novel link between periodontitis and ischemic heart disease: A case–control study

Ghorbani¹,

Esfahrood²,

Foroughi³

2023

Dent. Med. Probl.

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Background. Periodontitis is a chronic inflammatory disease and might be a potential risk factor for ischemic heart disease (IHD). However, the link between periodontitis and atherosclerosis is not yet fully understood. Paraoxonase-1 (PON-1) is a new biomarker representing both anti-atherosclerotic and antioxidant activity, which also acts against dental biofilm formation and periodontitis. The possible contributing role of PON-1 in the relationship between periodontitis and atherosclerosis has not been studied to date. Objectives.The aim of the present study was to investigate the serum level of PON-1 with regard to the periodontal status in IHD patients. Material and methods.In this case-control study, 67 patients with IHD underwent a periodontal examination and were accordingly allocated to one of the 2 study groups: the case group with chronic periodontitis (n = 36); or the control group with a healthy periodontium (n = 31). Serum PON-1 activity was measured by means of colorimetric analysis.Results. There were no significant differences between the groups in terms of demographic data, cardiac risk factors, initial biochemical test results, cardiac pump function, and the number of grafted vessels. The activity of PON-1 in cardiac patients suffering from periodontitis was significantly lower than in cardiac patients with a healthy periodontal status (53.01 ±7.53 U/mL and 59.11 ±9.95 U/mL, respectively; p = 0.007).Conclusions. This finding suggests that the combination of IHD and periodontitis is associated with lower PON-1 activity. Further studies might be required to assess the possible role of periodontal treatment in increasing PON-1 activity and reducing IHD severity.

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Biochemistry of Serum and Saliva in Obese Individuals with Periodontitis : Case - Control Study

Cited by 6 publications

References 44 publications

Association of C-Reactive Protein with Risk of Complications of diabetic nephropathy

Association of C-Reactive Protein with Risk of Complications of diabetic nephropathy

Changes of Salivary Interleukine-17, Apelin, Omentin and Vaspin Levels in Normal Subjects and Diabetic Patients with Chronic periodontitis

Paraoxonase-1, a novel link between periodontitis and ischemic heart disease: A case–control study

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