Association of C-Reactive Protein with Risk of Complications of diabetic nephropathy

Abstract

Background: Diabetic nephropathy become the main cause of chronic renal diseases in the world, that have been demonstrated high mortality rate and disability in patients with diabetes mellitus. Many recent studies demonstrate the associations of CRP and development of renal impairment in type two diabetic patients demonstrating the relation between systemic inflammation and glycemic control and consequently with severity of diabetic complications. Aim of study: evaluate the role of CRP and to analyze any correlation of CRP with nephropathy complications of diabetes. Material: the study was a cross sectional study of 62 type tow diabetic patients attended to Kirkuk general Hospital and 28 healthy subjects. Patient group was separated into two groups first include those have diabetic nephropathy and the second group include patient s without nephropathy. CRP level in serum sample was evaluated and albumin-creatinine ratio in random urine samples were calculated. Results: the present study revealed that the CRP serum concentration was significantly high in patient with nephropathy than those without nephropathy (P< 0.01). Also, demonstrated that the urine albumin-creatinine ratio was significantly increased in patients with nephropathy as compared with those without nephropathy as well as there is a strong positive correlation between CRP and urine albumin-creatinine ratio. Conclusion: A positive correlation of CRP with albumin-creatinine ration indicating the role of CRP in development of DN and possibility of used CRP measurement to predicate the DN development in type two diabetic patients. also supports the treatment targeting inflammatory mediators in improving diabetic complication.

Retinol Binding Protein 4 as a Recent Biomarker for Prediction of Diabetic Nephropathy in Type 2 Diabetic Patients

“…In agreement with our study CRP plays an important role in mesenchymal cell proliferation by release of proinflammatory cytokines in addition to increase glomerular albumin permeability which finally lead to albuminuria [16]. This result agrees with [17] who found that there was a significant higher CRP level in patients' group than that of healthy control group and the concentration of CRP in serum samples was higher in diabetic patients with nephropathy than those without nephropathy. [18] reported that microalbuminuria was accompanied by elevated HsCRP, suggesting activation of inflammatory pathways in the progression of renal disease in Type 2 diabetic patients which is in agreement with our findings.…”

Study of association between C-reactive protein and albuminuria in type 2 diabetes mellitus

“…(p<0.001). 25 The mean urea level in the Group with normal CRP levels was 30 mg/dl with std deviation of 8.5 mg/dl The mean urea level in the group with elevated CRP was 34.2 mg/dl with a std deviation of 13.5 mg/dl. The difference between the two groups was statistically significant (p<0.001).…”

Leucocyte Value as a Signs of Microvascular Inflammation in Type 2 Diabetes Mellitus Patients

“…The chronic inflammatory response causes diabetes complications by inducing massive endothelial injury and an increase in several mediators and oxidative stress (Amelia et al, 2021;Beandrade et al, 2022;Burgos-Morón et al, 2019). C-reactive protein and creatinine are parameters that can be used as a sign of acute inflammation in patients with type 2 diabetes mellitus (Amelia et al, 2019;Zbaar et al, 2022). In addition, the parameter HbA1C value has a relationship with fasting blood glucose levels.…”