Biochemical findings in multiple sclerosis

Delmotte, P.; Demonty, L.

doi:10.1007/bf00313357

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…Because of these difficulties with respect to clinical presentation and differential diagnosis, paraclinical tests are very important in establishing the diagnosis of childhood MS. Oligoclonal bands have been found in more than 90% of adult patients with clinical definite MS (27), and the significance of intrathecal oligoclonal bands in CSF of adults suspicious of MS is unquestionable (27)(28)(29)(30). In childhood MS, changes in C S F proteins have not been specifically evaluated.…”

Section: Discussionmentioning

confidence: 99%

Diagnosing multiple sclerosis in childhood

Lieshout

Engelen

Sanders

et al. 1993

Acta Neurologica Scandinavica

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By presenting the cases of 3 children with laboratory supported definite multiple sclerosis [LSDMS] according to Poser's diagnostic criteria, we illustrate the difficulties of diagnosing MS in childhood. In search for appropriate diagnostic criteria for childhood MS, the literature on childhood MS is reviewed, and the 3 cases presented are compared with the 15 hitherto reported with the diagnosis LSDMS. Specific difficulties of diagnosing MS in childhood are discussed. They include history taking in children, the multiple differential diagnostic possibilities, and the various clinical presentations. Due to these specific difficulties in childhood MS, we conclude that a strict use of Poser's criteria is indispensable, especially in childhood MS.

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Section: Discussionmentioning

confidence: 99%

Diagnosing multiple sclerosis in childhood

Lieshout

Engelen

Sanders

et al. 1993

Acta Neurologica Scandinavica

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Isoelectric focusing and quantitative estimation of cerebrospinal fluid and serum IgG in idiopathic polyneuropathy

et al. 1980

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Isoelectric focusing and quantitative estimation of serum and CSF IgG were performed in 85 patients with idiopathic polyneuropathy (IP), subdivided according to the clinical course (acute, subacute, recurrent, chronic). Acute IP very frequently had an increase of oligoclonal and/or polyclonal serum IgG during the progressive phase and blood-CSF barrier damage accompanied by polyclonal IgG intrathecal synthesis during the stationary phase. Polyclonal IgG intrathecal synthesis was also present in several not acute IP and seemed to forecast unfavorable course. Oligoclonal IgG synthesis occurs very rarely within CSF but is a frequent finding in serum of patients with IP. Abnormalities of the IgG serum pattern are neither specific for any clinical course of IP nor of prognostic value. The possible significance of such findings is discussed.

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