Biochemical diagnosis of liver disease

Abstract

It is important that clinicians and laboratorians, including clinical chemists and pathologists, recognize and understand the clinical significance of abnormal liver function tests. The liver regulates many important metabolic f u n c t i o n s . Hepatic injury is associated with distortion of these metabolic functions. Hepatic disease can be evaluated and diag.nosed by determining serum concentrations of a number of serum analytes. Many serum analytes exist to assist in the biochemical diagnosis of liver disease. The focus of this paper is on the analytes which are associated with hepatic necrosis, cholestasis, defects in excretion and end stage hepatic disease which results in decreased synthetic function. The abnormalities of these serum analytes will be correlated with the important types of liver disease.

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

“…So it has a surprising role in the maintenance, performance and homeostasis of the body (Ahsan et al, 2009). Hepatic damage is associated with distortion of these metabolic functions (Wolf, 1999). Liver damage is associated with cellular necrosis, increase in tissue lipid peroxidation and depletion of reduced glutathione levels.…”

Nigella sativa seeds protect against hepatotoxicity and dyslipidemia induced by carbon tetrachloride in mice

“…Hepatic damage caused by chemicals (or) infectious agents is associated with distortion of these metabolic functions (Wolf, 1999;Cullen, 2005 ) and may lead to progressive liver fibrosis and ultimately cirrhosis and liver failure (Anand, 1999). However, no effective treatment that delays these complications has yet been found.…”

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

“…One important and sensitive test employed in the diagnosis of hepatic disease is the serum bilirubin concentration, which provides essential information on how well the liver is functioning (32). Bilirubin is a product of the chemical breakdown of hemoglobin that increases water solubility in hepatocytes in conjugation with glucuronic acid (33).…”