Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Mirshahvalad, Sajedeh; Feizi, Farideh; Barkhordar, Aghdas; Bahadoram, Mohammad; Houshmand, Gholamreza; Pouramir, Mahdi

doi:10.17795/jjnpp.33392

Cited by 12 publications

(5 citation statements)

References 39 publications

(48 reference statements)

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“…51 In another study evaluating the antioxidant capacity of arbutin; It has been demonstrated that lipid peroxidation and fibrosis observed in the liver tissue of CCl 4 injected rats, with ARB administration, decreased lipid peroxidation to normal levels and ARB administration may have a protective effect on the liver. 52…”

Section: Fa Composition Of Erythrocytesmentioning

confidence: 99%

Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

Akkoyun¹,

Aydın²,

Akkoyun³

et al. 2022

IJPER

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Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO 3 ) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO 3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO 3 + ARB. At the end of the 5 th day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results:

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Section: Fa Composition Of Erythrocytesmentioning

confidence: 99%

Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

Akkoyun¹,

Aydın²,

Akkoyun³

et al. 2022

IJPER

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“…In various studies, it is revealed that arbutin formulations can be useful for the treatment of various diseases due to its multi‐target biological effects such as treatment of hyperpigmentation disorders (Ayumi, Sahudin, Hussain, Hussain, & Samah, 2019; Park et al, 2019), anti‐diabetic (Lv et al, 2019), wound healing (Polouliakh et al, 2020), anti‐osteoporosis (Bonifacio et al, 2020), treatment of acute lung injury (Ye et al, 2019), management of cardiac hypertrophy (Nalban et al, 2020), anticancer (Jiang et al, 2018; Safari et al, 2020; Wang, Wang, Li, Zhang, & Wang, 2020), antioxidant activity (Bonifacio et al, 2020), treatment of optic nerve injury (Ebrahim‐Tabar, Nazari, Pouramir, Ashrafpour, & Pourabdolhossein, 2020; Zhao, Wang, Qin, & Wang, 2019), treatment of central nervous system disorders (Ahmadian, Ghasemi‐Kasman, Pouramir, & Sadeghi, 2019; Dastan et al, 2019; Ding et al, 2020), hepatoprotective activity (Mirshahvalad et al, 2016), effect on human mesenchymal stem cells (Bonifacio et al, 2020; Jamil, Crowe, Tablin, & Oliver, 2005), radioprotective effect (Nadi, Elahi, Moradi, & Banaei, 2019), antimicrobial (Nadi et al, 2019), antiaging (Zhou et al, 2017), antitussive (Koul, Kumar, Yadav, & Jin, 2020), diuretic (Myagchilov, Mineev, Sokolova, Gerdasova, & Gorovoi, 2020), anti‐inflammatory (Lee & Kim, 2012; Zhou, Zhao, Li, & Reetz, 2019), inhibitory effects on melanin formation (Li, Du, & Du, 2018), estrogen‐like effects (Zeng et al, 2018), and cytoprotective effects (Seyfizadeh et al, 2012) etc.…”

Section: Chemical Characterizations and Therapeutic Effects Of Arbutin In Cosmetic And Pharmaceutical Preparationsmentioning

confidence: 99%

“…In vivo Mirshahvalad et al (2016) Cardiac hypertrophy Arbutin exhibited an anti-hypertrophic effect by decreasing TLR-4/NF-κb pathway.…”

Section: Chemical Characterizations and Therapeutic Effects Of Arbutin In Cosmetic And Pharmaceutical Preparationsmentioning

confidence: 99%

“…In (Mirshahvalad et al, 2016), effect on human mesenchymal stem cells (Bonifacio et al, 2020;Jamil, Crowe, Tablin, & Oliver, 2005), radioprotective effect (Nadi, Elahi, Moradi, & Banaei, 2019), antimicrobial (Nadi et al, 2019), antiaging (Zhou et al, 2017), antitussive (Koul, Kumar, Yadav, & Jin, 2020), diuretic (Myagchilov, Mineev, Sokolova, Gerdasova, & Gorovoi, 2020), anti-inflammatory (Lee & Kim, 2012;Zhou, Zhao, Li, & Reetz, 2019), inhibitory effects on melanin formation (Li, Du, & Du, 2018), estrogen-like effects (Zeng et al, 2018), and cytoprotective effects (Seyfizadeh et al, 2012) etc.…”

Section: Antiapoptotic Role and Radioprotectormentioning

confidence: 99%

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A comprehensive review of the therapeutic potential of α‐arbutin

Saeedi

Khezri

Zakaryaei

et al. 2021

Phytotherapy Research

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Cosmetic dermatology preparations such as bleaching agents are ingredients with skin‐related biological activities for increasing and improving skin beauty. The possibility of controlling skin hyperpigmentation disorders is one of the most important research goals in cosmetic preparations. Recently, cosmetics containing herbal and botanical ingredients have attracted many interests for consumers of cosmetic products because these preparations are found safer than other preparations with synthetic components. However, high‐quality trial studies in larger samples are needed to confirm safety and clinical efficacy of phytotherapeutic agents with high therapeutic index. Arbutin (p‐hydroxyphenyl‐β‐d‐glucopyranoside) is a bioactive hydrophilic polyphenol with two isomers including alpha‐arbutin (4‐hydroxyphenyl‐α‐glucopyranoside) and β‐arbutin (4‐hydroxyphenyl‐β‐glucopyranoside). It is used as a medicinal plant in phytopharmacy. Studies have shown that alpha‐arbutin is 10 times more effective than natural arbutin. A comparison of IC50 values showed that α‐arbutin (with concentration 2.0 mM) has a more potent inhibitory activity on human tyrosinase against natural arbutin (with higher concentration than 30 mM). A review of recent studies showed that arbutin could be beneficial in treatment of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes, etc. This study was designed to describe the therapeutic efficiencies of arbutin.

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“…Due to its mildly therapeutic properties, arbutin is also widely used in food, health-care, and cosmetic industries. Previous studies suggested that arbutin may prominently mitigate liver damage caused by CCl 4 (carbon tetrachloride), radiation, lipopolysaccharides (LPSs), and D-galactosamine (D-GalN) ( Mirshahvalad et al, 2016 ; Nadi et al, 2019 ; Jurica et al, 2020 ). But there have been limited research studies on the potential effect of arbutin against cholestatic liver disease and its fundamental mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Arbutin Alleviates the Liver Injury of α-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation

Liao

et al. 2021

Front. Cell Dev. Biol.

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Cholestasis is a kind of stressful syndrome along with liver toxicity, which has been demonstrated to be related to fibrosis, cirrhosis, even cholangiocellular or hepatocellular carcinomas. Cholestasis usually caused by the dysregulated metabolism of bile acids that possess high cellular toxicity and synthesized by cholesterol in the liver to undergo enterohepatic circulation. In cholestasis, the accumulation of bile acids in the liver causes biliary and hepatocyte injury, oxidative stress, and inflammation. The farnesoid X receptor (FXR) is regarded as a bile acid–activated receptor that regulates a network of genes involved in bile acid metabolism, providing a new therapeutic target to treat cholestatic diseases. Arbutin is a glycosylated hydroquinone isolated from medicinal plants in the genus Arctostaphylos, which has a variety of potentially pharmacological properties, such as anti-inflammatory, antihyperlipidemic, antiviral, antihyperglycemic, and antioxidant activity. However, the mechanistic contributions of arbutin to alleviate liver injury of cholestasis, especially its role on bile acid homeostasis via nuclear receptors, have not been fully elucidated. In this study, we demonstrate that arbutin has a protective effect on α-naphthylisothiocyanate–induced cholestasis via upregulation of the levels of FXR and downstream enzymes associated with bile acid homeostasis such as Bsep, Ntcp, and Sult2a1, as well as Ugt1a1. Furthermore, the regulation of these functional proteins related to bile acid homeostasis by arbutin could be alleviated by FXR silencing in L-02 cells. In conclusion, a protective effect could be supported by arbutin to alleviate ANIT-induced cholestatic liver toxicity, which was partly through the FXR pathway, suggesting arbutin may be a potential chemical molecule for the cholestatic disease.

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Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Abstract: Background: The antioxidant and anti-inflammatory effects of arbutin protect against a number of diseases. Objectives: The present study evaluated the protective effect of arbutin against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.

Cited by 12 publications

References 39 publications

Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

A comprehensive review of the therapeutic potential of α‐arbutin

Arbutin Alleviates the Liver Injury of α-Naphthylisothiocyanate-induced Cholestasis Through Farnesoid X Receptor Activation

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