Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

Abstract

Hepatoprotective effect of the aqueous leaf extract of Andrographis paniculata was investigated against CCl4 -induced hepatic injury in rats. Significant (P<0.05) increase of serum levels of alanine aminotransferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total bilirubin (TBL), direct bilirubin (DBL), total cholesterol (CHL), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and malondialdehyde (MDA) in CCl4 intoxicated rats were restored to normal levels when treated with the extract and CCl4. Significant (P<0.05) decrease of serum levels of total protein (TP), albumin (ALB), high density lipoprotein (HDL) and reduced glutathione (GSH) in CCl4 intoxicated rats were restored to normal levels when treated with the extract and CCl4. The LD50 of the leaf extract was greater than 3000 mg/kg. The study demonstrated that A. paniculata possesses significant hepatoprotective effects and may be the source of lead compound in the management of liver diseases.

Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4-induced liver damage in rats

“…On the other hand, by increasing HDL production and decreasing LDL production, it facilitates the breakdown of acetate by liver. These findings of our study were consistent with the findings of other studies [32] , [29] , [34] .…”

Andrographolide and Resveratrol Effect against Hepatocellular Carcinoma induced in Male Albino Rats

“…These results were in a harmony with many studies; Nasir et al, (42) who reported that the treatment with Andrographolide show reduction in the levels of ALT and AST towards the normal value is an indication of regeneration process. Chen et al, (29) reported that Andrographolide decrease activity of ALT and AST.…”

Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes

“…The antidiabetic effects of A. paniculata have been investigated by number of researchers from in silico studies to human evidence (Kooti et al, 2016;Niranjan et al, 2010;Nizmawardini et al, 2013;Xu et al, 2007Xu et al, , 2010. It has also a wide range of pharmacological effects (Akhtar et al, 2016;Jayakumar et al, 2013;Rajasekaran et al, 2016), including hepatoprotective (Nasir et al, 2013;Vetriselvan and Middha, 2016), antioxidant (Dandu and Inamdar, 2009), and anti-inflammatory (Zou et al, 2016), which are beneficial for people with T2DM, since it may help minimize complications of diabetes. On the other hand, Syzygium polyanthum (Wight.)…”