Biochemical changes in the liver and gill of Cathorops spixii collected seasonally in two Brazilian estuaries under varying influences of anthropogenic activities

Azevedo, Juliana de Souza; Braga, Elisabete S.; Assis, Helena C. Silva de; Ribeiro, Ciro Alberto de Oliveira

doi:10.1016/j.ecoenv.2013.06.021

Cited by 31 publications

(32 citation statements)

References 48 publications

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“…Aphantoxins may reduce the synthesis of AChE in these neurons, thus inhibiting neurotransmission via voltage-gated sodium channels (Hussien et al, 2013). The present and previous results suggest that aphantoxins/PSPs may damage the structure and function of the liver by inhibiting AChE activity and thus affecting cholinergic neurotransmission in zebrafish liver (Azevedo et al, 2013).…”

Section: Ache Activitymentioning

confidence: 67%

“…Decreased AChE activity may be associated with damage to cholinergic neurons that innervate/modulate liver, because AChE is located in the synapse between neurons/non-neurons in these pathways (Azevedo et al, 2013). Aphantoxins may reduce the synthesis of AChE in these neurons, thus inhibiting neurotransmission via voltage-gated sodium channels (Hussien et al, 2013).…”

Section: Ache Activitymentioning

confidence: 99%

“…Previous studies have investigated the effects of atrazine, pesticides and microcystins on these parameters in animals (Hussien et al, 2013;Vasanthi et al, 2014). However, there is little information on the effects of cyanobacterial neurotoxins or PSPs on these markers of hepatic detoxification and metabolism in fish (Apte and Krishnamurthy, 2011;Azevedo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Zhang

et al. 2014

Aquatic Toxicology

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Section: Ache Activitymentioning

confidence: 67%

Section: Ache Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Zhang

et al. 2014

Aquatic Toxicology

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“…Acetylcholinesterase (AChE) and monoamine oxidase (MAO) are two vital enzymes that decompose cholinergic and monoamine neurotransmitters in fish gills, such as acetylcholine produced by parasympathetic nerves and norepinephrine/epinephrine from sympathetic nerves, respectively (Askar et al, 2011;Porteus et al, 2013). Previous studies have reported abnormalities in these parameters in the gills of fish induced by insecticides, pesticides, and toxicants (David et al, 2004;Oruc and Usta, 2007;Azevedo et al, 2013). However, there is relatively little data regarding alterations in the aforementioned parameters in the gills of fish caused by cyanobacterial neurotoxins or PSPs.…”

Section: Introductionmentioning

confidence: 99%

Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill

et al. 2016

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“…The GST are phase II enzymes that play a major role in conjugation reactions and detoxification mechanisms by reducing organic hydroperoxides (ROOH). GST hydrolyzed lipophilic compounds are subsequently excreted as a watersoluble non-reactive conjugate (Simonato et al, 2011;Azevedo et al, 2013). Catalase is an essential enzyme that catalyzes the conversion of hydrogen peroxide (H 2 O 2 ) into water and oxygen, thereby preventing its conversion to hydroxyl radicals and reducing oxidative stress levels (Gonçalves-Soares et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of manganese on fat snook Centropomus parallelus (Carangaria: Centropomidae) exposed to different temperatures

et al. 2017

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This study evaluates the effects of exposure to manganese (Mn 2+ ) for 96 hours at two different temperatures (24 and 27°C) on juveniles of Centropomus parallelus through the activities of glutathione S-transferase (GST) and catalase (CAT), micronuclei test (MN) and comet assay. The GST activity did not show any significant difference between the groups exposed to Mn 2+ and the respective control groups; in contrast, a major increase in the CAT activity was observed at 27°C in the group exposed to Mn 2+ compared to the control group. The genotoxic analyses showed that in all animals exposed to Mn 2+, the number of red cells with micronuclei increased significantly compared to the respective control groups. There was also a significant increase in the incidence of DNA damage in the groups exposed to Mn 2+. At a temperature of 24ºC, animals exposed to Mn 2+ had more DNA damage than those at 27°C. It is likely that the increase in temperature can also induce oxidative stress. Thus, we conclude that manganese is toxic to the fat snook juveniles, causing genotoxic damage, and when associated with an increase in temperature, manganese can also provoke an increase in oxidative stress.Keywords: Biomarkers, DNA damage, Enzymes, Genotoxicity, Metal, Micronuclei.Este estudo avaliou os efeitos da exposição ao manganês (Mn 2+ ), após 96 horas, a duas temperaturas (24 e 27°C) em juvenis de Centropomus parallelus por meio de análises bioquímicas (atividade das enzimas glutationa S-transferase (GST) e catalase (CAT)) e genotóxicas (teste do micronúcleo e ensaio cometa). A atividade da GST não mostrou diferença significativa entre os grupos expostos ao Mn 2+ e os seus respectivos grupos controle, enquanto que um aumento significativo na atividade da CAT foi observado a 27°C no grupo exposto ao Mn 2+ , quando comparado ao grupo controle. As análises genotóxicas mostraram que os animais expostos ao Mn 2+ tiveram aumento significativo na quantidade de células com micronúcleo em relação aos seus grupos de controles. Houve também aumento significativo na incidência de danos ao DNA nos grupos expostos a esse contaminante. Na temperatura de 24°C, os animais expostos ao Mn 2+ tiveram maior quantidade de danos no DNA em relação a 27°C. É provável que o aumento da temperatura também possa induzir o estresse oxidativo. Assim, concluímos que o manganês é tóxico para os juvenis de robalo, causando dano genotóxico, e quando associado a um aumento da temperatura, também pode provocar um aumento no estresse oxidativo.

show abstract

Biochemical changes in the liver and gill of Cathorops spixii collected seasonally in two Brazilian estuaries under varying influences of anthropogenic activities

Cited by 31 publications

References 48 publications

Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Respiratory toxicity of cyanobacterial aphantoxins from Aphanizomenon flos-aquae DC-1 in the zebrafish gill

Effects of manganese on fat snook Centropomus parallelus (Carangaria: Centropomidae) exposed to different temperatures

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