Biochemical and molecular mechanisms of occurrence of occupational bronchopulmonary pathology

Кузьмина, Л.П.

doi:10.18093/0869-0189-2008-0-4-107-110

Pulʹmonologiâ (Mosk.)

2008

DOI: 10.18093/0869-0189-2008-0-4-107-110

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Biochemical and molecular mechanisms of occurrence of occupational bronchopulmonary pathology

Л.П. Кузьмина¹

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Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis

et al. 2018

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A comparative evaluation of serum concentrations of cytokines and IgE production in patients with occupational bronchial asthma (BA) caused by exposure to the toxic-dust factor of the aluminum industry and patients with asthma of unprofessional genesis was carried out. A more pronounced pro-inflammatory response has been found in patients with occupational BA characterized by hyperproduction of IL-1b, IL-8. While for persons with non-professional asthma, a decrease in IL-1b, IL-5, IL-10 is characteristic. The common pattern of the detected changes in the patients of both groups consists in an increase in the production of IgE (6 times in patients with occupational BA and 8.9 times with non-occupational asthma) and a decrease in serum concentrations of TNF-a. Various cytokine manifestations in occupational and unprofessional BA may be associated with different etiopathogenetic mechanisms of disturbance of intra-immune regulation, and also confirms the professional conditionality of the revealed changes in patients with BA who work in the aluminum industry.

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Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis

et al. 2018

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Influence exerted by somatic pathology on risks of occupational lung fibrosis in workers employed at refractory production

Obukhova¹,

Будкарь²,

Gurvich³

et al. 2020

Health Risk Analysis

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Occupational lungs and bronchial pathology occurs not only under exposure to dusts, their aerosol structure and aggression, but also depends on individual properties of a body. The latter can determine either increased body resistance or susceptibility to occupational pathology occurrence. Our research goal was to determine influence exerted by somatic pathology on occupational lung fibrosis occurrence as well as to estimate prevalence of risk factors for cardiovascular and metabolic pathology occurrence in workers employed at refractory production. At the first stage 449 workers employed at refractory production were examined at a periodical medical examination (PME). Patients’ average age was 41.59±0.45 and average work experience was 14.47±0.39 years. At the second stage 172 workers were examined at an occupational pathology center; 75 out of them were workers who had silicosis and were included into the test group and the remaining 97 workers didn’t have any occupational pathology and were included into the reference group. Both groups were comparable as per sex (p = 0.0052) and work experience under exposure to dusts (р = 0.862). Workers examined at a PME most frequently had overweight and obesity (68 %). Arterial hypertension (AH) prevalence amounted to 19.5%; carbohydrate metabolism disorders, 19.8 %; 48.1 % workers had hypercholesterolemia. Patients with silicosis had certain disorders significantly more frequently than workers with long work experience but without any occupational pathologies; those disorders were AH, cardiac muscle hypertrophy in the left ventricle, ischemic heart disease, heart rate disorders, as well as mixed (obstructive and restrictive) breath mechanics disorders. We determined some factors that authentically produced certain effects on occupational lung fibrosis occurrence in workers employed at refractory production. Median time of silicosis occurrence was significantly shorter (by 11.5 years) among workers with severe AH, arrhythmia (by 13 years), lower hemoglobin in blood (by 11.5 years). Besides, silicosis occurred significantly earlier (by 10.8) among women than among men.

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Immunoregulatory markers of bronchopulmonary diseases in workers of the aluminium industry

Бодиенкова

Боклаженко

Ushakova

2019

Myditsina truda I promyshlennaya ekologiy

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The laboratory immunologic study covered 106 male workers of aluminium industry, aimed to reveal features of changes in serum immunoglobulines and cytokines levels in accordance with occupational bronchopulmonary disease type: chronic nonobstructive bronchitis, chronic obstructive lung disease (COLD), bronchial asthma. General trend in the revealed changes in the patients with bronchopulmonary diseases is increased serum levels of Ig (IgA, IgM, IgG), anti-inﬂ ammatory cytokines (IL–1b, IL-8) and lower production (TNF-a, IL-4). Findings are multidirectional changes INF-g responsible for inﬂammatory response mobilization — that was increased vs. reference values in bronchial asthma patients, and in chronic nonobstructive bronchitis patients was lower than in reference group, and higher than in patients with COLD. The changes revealed were associated with disordered ratio IL-4/INF-g. Diﬀerences were observed for pleiotropic IL-2: it was hyperproduced in the workers with chronic nonobstructive bronchitis, but in the bronchial asthma and COLD patients it was decreased vs. the reference group and vs. the chronic nonobstructive bronchitis patients. The authors justified informative criteria of bronchial asthma diagnosis.

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Biochemical and molecular mechanisms of occurrence of occupational bronchopulmonary pathology

Abstract: .

Cited by 3 publications

References 3 publications

Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis

Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis

Influence exerted by somatic pathology on risks of occupational lung fibrosis in workers employed at refractory production

Immunoregulatory markers of bronchopulmonary diseases in workers of the aluminium industry

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