Introduction. Elderly people are among the most important social groups in Russian society, remaining the least protected, socially and biologically vulnerable part of the population. The objective of the study is to rank and assess the risk factors and health status of older people. Materials and Methods. 40 elderly persons aged 60 to 87 years were examined. The average age was 71.2 ± 7.4 years. Clinical, audiometric, stabilometric, psychological examination, biochemical blood test, osteodensitometry, ultrasound examination were carried out. An assessment of the health-related quality of life and diet is given. Statistica software was used for statistical processing. V.10 Results. On average, 5.3 diseases were found to be detected per one older person. This indicates the polymorbidity of the pathology. At the same time, more than half of the examined persons were found to have combined vascular lesions (52.5%) with lesions of the vessels of the brain and heart, accompanied by impaired cholesterol metabolism. The analysis of the indicators of the quality of life scales in the elderly population made it possible to establish pronounced problems associated with physical and emotional health and the deficit in the intake of B vitamins and protein in the diet. Conclusion. The older persons differ due to polymorbidity pathology. The analysis of the indicators of the quality of life scales in the elderly allowed establishing the presence of pronounced problems associated with physical and emotional health. It demonstrates the presence of increased depletion of mental activity and fatigue, and the lack of activation processes, which may further affect the limitation of daily activities and reduce the health-related life quality.

It was found that the appearance of respiratory diseases among workers was established to be associated with the impact of aerosols with the complex chemical composition, exceeding corresponding MAC. Among respiratory diseases in workers there were detected predominantly chronic non-obstructive bronchitis - 59.15%, and chronic obstructive pulmonary disease (COPD) - in 35.2% of cases. In the analysis of spirometric indices of examined patients the vast majority (76.3%) of them showed disturbances of the bronchial patency of mild to moderate degree of the pronouncement. As a result of the implementation offlexible bronchoscopy there was established the presence of a diffuse lesion of bronchi with a predominance of subatrophic and atrophic processes in the mucosa. It was found that under the increase of the concentration of HF in the air of industrial premises the probability of bronchial obstruction and deterioration of the tracheobronchial patency in aluminum smelter workers was established to elevate.

The laboratory immunologic study covered 106 male workers of aluminium industry, aimed to reveal features of changes in serum immunoglobulines and cytokines levels in accordance with occupational bronchopulmonary disease type: chronic nonobstructive bronchitis, chronic obstructive lung disease (COLD), bronchial asthma. General trend in the revealed changes in the patients with bronchopulmonary diseases is increased serum levels of Ig (IgA, IgM, IgG), anti-infl ammatory cytokines (IL–1b, IL-8) and lower production (TNF-a, IL-4). Findings are multidirectional changes INF-g responsible for inflammatory response mobilization — that was increased vs. reference values in bronchial asthma patients, and in chronic nonobstructive bronchitis patients was lower than in reference group, and higher than in patients with COLD. The changes revealed were associated with disordered ratio IL-4/INF-g. Differences were observed for pleiotropic IL-2: it was hyperproduced in the workers with chronic nonobstructive bronchitis, but in the bronchial asthma and COLD patients it was decreased vs. the reference group and vs. the chronic nonobstructive bronchitis patients. The authors justified informative criteria of bronchial asthma diagnosis.

Arterial hypertension is one of the most spread chronic non-specific human diseases and according to World Health Organization, is due to 30% of all-death outcomes in general. The aim of this study was to investigate the efficacy of Kardiovitin in the integrated treatment of arterial hypertension. Methods. A total of twenty patients took part in the study - seventeen women (average age – 64.5±8.7 years, average weight – 77.8±11.4 kg) and three men (average age – 54.6±12.4 years, average weight – 114±402 kg). A questionnaire, anamnesis, study of risk factors for hypertension, ECG, general blood analysis, general urine analysis, biochemical blood tests, were included in the examination program before and after treatment. Statistical processing was carried out with the program “Statistica 6.0”. Differences at p<0.05 were considered statistically significant. Results. It was observed a statistically significant decrease in systolic blood pressure - 120.0 (120.0-130.0) at p<0.05, in total cholesterol – 5.6 (4.6-6.4), LDL cholesterol – 3.2 (3.1-3.5) at p<0.05 after 2 months Kardiovitin therapy in addition to the standard hypotensive therapy. Conclusion. The results of the study indicate the efficacy of including Kardiovitin in the scheme for basic antihypertensive therapy as a source of bioflavonoids involved in the stabilization of the vascular wall.

Diabetes mellitus is one of the most serious medical, social, and economic health problems in all countries of the world. The incidence of diabetes mellitus in the world doubles every 10–15 years, acquiring the character of a non-infectious epidemic. Therefore, it is extremely important to search for new drugs that help normalize glycemia, prevent complications of diabetes mellitus, and improve the quality of life of patients. These drugs include “Neo inulin”, which has a hypoglycemic, antioxidant, hepatoprotective and angioprotective effect.The aim: to evaluate the effectiveness of “Neo inulin” in the complex treatment of patients with type 2 diabetes mellitus.Materials and methods. The study involved 18 women (average age – 64.5 ± 8.7 years, average weight – 77.8 ± 11.4 kg) and 3 men (average age – 54.6 ± 12.4 years, average weight – 114 ± 40.2 kg). The average duration of type 2 diabetes was 11.0 (7.0–12.0) years. “Neo inulin” was prescribed as 2 capsules per day for 12 weeks in the complex of basic diabetes therapy To assess the effectiveness of therapy, a study of the quality of life related to health, a biochemical blood test (glycated hemoglobin), a clinical minimum (CBC, OAM, ECG, blood glucose) was carried out, the functional characteristics of tissue blood flow were investigated, and the ankle-brachial index (ABI) was determined. Statistical processing of the results was carried out using the Statistica 6.0 software package (StatSoft Inc., USA). Differences were considered statistically significant at p < 0.05.Results. Statistically significant differences were revealed in the values of all scales of health-related quality of life in patients in the groups before and after treatment with “Neo Inulin”, including the total physical and mental components. An improvement in the functioning of microcirculatory regulation mechanisms was noted, which is confirmed by a statistically significant increase in ABI (1.0 and 0.8 on the right; 0.9 and 0.8 on the left, respectively; p < 0.05) and the coefficient of microcirculation variation (9.2 and 8.3, respectively; p < 0.05). In 57,1 % of cases (12 people), the level of glycated hemoglobin was normalized.Conclusion. The use of a treatment regimen that includes “Neo Inulin” improves the effectiveness of treatment and improves the quality of life of patients with type 2 diabetes mellitus.