Comparative characteristics of cytokine and IgE levels in patients with bronchial asthma of professional and non-professional genesis

Abstract

A comparative evaluation of serum concentrations of cytokines and IgE production in patients with occupational bronchial asthma (BA) caused by exposure to the toxic-dust factor of the aluminum industry and patients with asthma of unprofessional genesis was carried out. A more pronounced pro-inflammatory response has been found in patients with occupational BA characterized by hyperproduction of IL-1b, IL-8. While for persons with non-professional asthma, a decrease in IL-1b, IL-5, IL-10 is characteristic. The common pattern of the detected changes in the patients of both groups consists in an increase in the production of IgE (6 times in patients with occupational BA and 8.9 times with non-occupational asthma) and a decrease in serum concentrations of TNF-a. Various cytokine manifestations in occupational and unprofessional BA may be associated with different etiopathogenetic mechanisms of disturbance of intra-immune regulation, and also confirms the professional conditionality of the revealed changes in patients with BA who work in the aluminum industry.

Comparative Assessment of Neurochemical Indices in Patients with Occupational Pathology Caused by Physical and Chemical Factors

“…In patients with CMI, the level of IL-1β was decreased compared to the control group and VD patients (p < 0.00001). It should be noted that in previous studies of patients with occupational pathology caused by chronic exposure to toxic compounds in the aluminum industry, a decreased IL-1β level was observed as well [20]. IL-1β is known to stimulate PGE synthesis in the hypothalamus, thus leading to the development of inflammatory and neuropathic reactions and causing depression, fatigue, social maladaptation, decreased energy output, etc [16].…”