Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup

Shati, Ali A.; Elsaid, Fahmy G.; Hafez, Elsayed E.

doi:10.1016/j.neuroscience.2010.11.043

Cited by 88 publications

(35 citation statements)

References 65 publications

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“…AChE activity was further significantly decreased in cerebral tissues of Al+saffron group. The biochemical changes support the neuroprotective potential of saffron under toxicity [114].…”

Section: Stsupporting

confidence: 54%

Medicinal plants with central nervous effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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“…AChE activity was further significantly decreased in cerebral tissues of Al+saffron group. The biochemical changes support the neuroprotective potential of saffron under toxicity [114].…”

Section: Stsupporting

confidence: 54%

Medicinal plants with central nervous effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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“…As the AD progresses, there is a constant decrease in the stages of rapid eye movement and non-rapid eye movement causing the patient to remain awake for too long [58], tacrine and metrifonate and the cholinergic agonist xanomeline these drugs are helpful for reducing the hallucinations than those persons who take a placebo [59].…”

Section: Treatment Of Behavioral Symptomsmentioning

confidence: 99%

Genetic Disorder Alzheimer

Rani

Singh

Arjuna

et al. 2017

Asian J Pharm Clin Res

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Alzheimer's disease (AD), slowly continuous neurological disorder, mostly appears in older >65 age that deals with the memory loss due to death or damage of brain cells and cognitive functions (thinking, reasoning, and behavior abnormalities) due to the accumulation of the specific protein (betaamyloid protein) which form plaque and fibers (tau tangles) in the brain. Not only the genetic factors are responsible but also most of the non-genetic factors are responsible for AD. Several mutations in the gene (APP, APOE, PENS1, PENS2 on chromosome no. 21, 19, 14, 1) are responsible for causing four types of AD. Memory loss is most common sign of AD. Predisposing factors of AD are hereditary, severe brain injury or traumatic, and metabolic diseases such as diabetes mellitus, hypercholesteremia, and obesity. Although treatment can manage some symptoms in few people, but there is no current mechanism to cure AD or stop its progression. Beta-secretase inhibitor molecule prevents the first step in a chain accumulation which leads to the formation of amyloid plaque in the brain. However, the scientist or researchers have established a compound NIC5-15 they have been found NIC5-15 has safe and effectual treatment which has been used to stabilize cognitive performance in patients with mild to moderate AD.

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“…In addition, there was an ameliorative change with saffron extract and honey syrup against AlCl 3 neurotoxicity. The obtained molecular results suggested that AlCl 3 made induction for BCL-W gene, which was an anticancer gene or belonged to the DNA repair system in the brain cells, as well as for R-spondin and inositol polyphosphate 4-phosphatase genes, which helped in cell proliferation [83][84].…”

Section: Crocus Sativusmentioning

confidence: 99%

Detoxification capacity and protective effects of medicinal plants (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup

Cited by 88 publications

References 65 publications

Medicinal plants with central nervous effects (part 2): plant based review

Medicinal plants with central nervous effects (part 2): plant based review

Genetic Disorder Alzheimer

Detoxification capacity and protective effects of medicinal plants (part 2): plant based review

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