Bioanalytical system for control of hemodialysis treatment based on potentiometric biosensors for urea and creatinine

Radomska, Anna; Koncki, Robert; Pyrzyńska, Krystyna; Głąb, Stanisław

doi:10.1016/j.aca.2004.06.048

Cited by 48 publications

(26 citation statements)

References 21 publications

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“…Most popular potentiometric detectors in FIA systems are electrodes selective towards ammonium ions (based on nonactin as an ionophore), used for determination of clinically important analytes, such as urea or creatinine [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. However, electrodes selective towards other ions can also be employed as detectors in enzymatic analytical systems.…”

mentioning

confidence: 99%

Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system

Górski

Mroczkiewicz

Pietrzak

et al. 2009

Analytica Chimica Acta

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mentioning

confidence: 99%

Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system

Górski

Mroczkiewicz

Pietrzak

et al. 2009

Analytica Chimica Acta

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“…Використан-ня глюкозовмісних розчинів, постійний моні-торинг рівня глюкози в крові під час сеансів рекомендовані для зниження ризику розвитку гіпоглікемічних станів у хворих на цукровий діабет, які перебувають в умовах хронічного гемодіалізу [5,6]. Крім того, для контролю ефективності процедури гемодіалізу та для зменшення часу перебування пацієнта в не-зручних умовах, необхідний постійний контр-оль основних уремічних токсинів -сечовини та креатиніну [7][8][9]. В сучасній лабораторній діагностиці для кількісного аналізу зазначених метаболітів існують колориметричні методи аналізу.…”

Section: вступunclassified

MULTIBIOSENSOR SYSTEM BASED ON pH-SENSITIVE FIELD-EFFECT TRANSISTORS FOR SIMULTANEOUS DETERMINATION OF GLUCOSE, CREATININE AND UREA

Солдаткін¹,

Марченко²,

Кукла³

et al. 2018

SEMST

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“…This system was susceptible to serious interference from NH 4 + , K + , and Na + ; subsequently, however, the researchers improved selectivity when a cation exchange column was incorporated. 16 Entrapment of CIH has been achieved within a composite film consisting of a polyion complex and pH-sensitive, inactive polypyrrole prepared by electropolymerization. 17 The microsensor measures pH changes that accompany the enzyme-catalyzed reaction.…”

Section: Enzyme Immobilization For Potentiometric Biosensorsmentioning

confidence: 99%

Electrochemical Creatinine Biosensors

2008

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To measure creatinine, electrochemical techniques have been coupled with a range of biological recognition elements in a variety of sensor configurations. (To listen to a podcast about this feature, please go to the Analytical Chemistry website at pubs.acs.org/ac.The measurement of creatinine levels in human blood or urine is clinically essential because the levels partially reflect the state of renal and muscle function. Creatinine is naturally produced by the body and is filtered from the bloodstream by the kidneys in relatively constant amounts every day. The normal physiological concentration is 40-150 µM, but it can exceed 1000 µM in certain pathological conditions. Blood levels >150 µM indicate the need to perform tests such as creatinine clearance. Values >500 µM indicate severe renal impairment, ultimately leading to dialysis or transplantation; 1 levels <40 µM indicate decreased muscle mass.The methods most often used for the clinical determination of creatinine are based on colorimetry. 2 However, the methods are affected by numerous metabolites and drugs found in biological samples, such as glucose, fructose, ketone bodies, ascorbic acid, and cephalosporins. 3,4 Introducing enzymes has increased specificity, but the methods also became complicated and less reliable. Large and expensive benchtop analyzers incorporating a number of electrochemical electrodes have been used in central clinical laboratories. Portable and handheld devices incorporating a single-use creatinine biosensor cartridge also have been used.The goal of biosensor engineering in the clinical laboratory setting is to reduce cost, time, and complexity of routine analysis of biological fluids; to enable near-patient testing of blood, urine, and saliva in medical centers; and ultimately to enable home testing by individuals. 5 This article looks at the developments in electrochemical creatinine biosensor research in terms of sensor design and analytical performance on the basis of the recognition element and the nature of transducer. Parameters and specific performance characteristics to consider include cost (<$10/ sensing strip), response time (<1.5 minutes [min]), detection limit (e10 µM), linear range (10-1000 µM), and lifetime (>1 year).

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Bioanalytical system for control of hemodialysis treatment based on potentiometric biosensors for urea and creatinine

Cited by 48 publications

References 21 publications

Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system

Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system

MULTIBIOSENSOR SYSTEM BASED ON pH-SENSITIVE FIELD-EFFECT TRANSISTORS FOR SIMULTANEOUS DETERMINATION OF GLUCOSE, CREATININE AND UREA

Electrochemical Creatinine Biosensors

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