Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system

Górski, Łukasz; Mroczkiewicz, Monika; Pietrzak, Mariusz; Malinowska, Elżbieta

doi:10.1016/j.aca.2009.04.013

Cited by 15 publications

(11 citation statements)

References 35 publications

(37 reference statements)

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“…Overall, the sensors incorporating any of the ionophores exhibited selectivity for carboxylates in general. For the most part, the sensors in this study were less selective for acetate than previously reported sensors based on derivatives of porphyrin or uranyl salophene [37,46,47,49]. While the sensors' selectivity for acetate was modest, selectivity for more lipophilic carboxylates, e.g., benzoate, was good.…”

Section: Potentiometric Selectivitycontrasting

confidence: 67%

Potentiometric Carboxylate Sensors Based on Carbazole-Derived Acyclic and Macrocyclic Ionophores

et al. 2020

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Solid-contact ion-selective electrodes with carbazole-derived ionophores were prepared. They were characterized as acetate sensors, but can be used to determine a number of carboxylates. The potentiometric response characteristics (slope, detection limit, selectivity, and pH sensitivity) of sensors prepared with different membrane compositions (ionophore, ionophore concentration, anion exchanger concentration, and plasticizer) were evaluated. The results show that for the macrocyclic ionophores, a larger cavity provided better selectivity. The sensors exhibited modest selectivity for acetate but good selectivity for benzoate. The carbazole-derived ionophores effectively decreased the interference from lipophilic anions, such as bromide, nitrate, iodide, and thiocyanate. The selectivity, detection limit, and linear range were improved by choosing a suitable plasticizer and by reducing the ionophore and anion exchanger concentrations. The influence of the electrode body’s material upon the composition of the plasticized poly(vinyl chloride) membrane, and thus also upon the sensor characteristics, was also studied. The choice of materials for the electrode body significantly affected the characteristics of the sensors.

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Section: Potentiometric Selectivitycontrasting

confidence: 67%

Potentiometric Carboxylate Sensors Based on Carbazole-Derived Acyclic and Macrocyclic Ionophores

et al. 2020

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“…in an FIA system developed for determination of acetylcholine with immobilized acetylcholinesterase and with detection using metalloporphyrin-based acetate ISE. 378 The most commonly used variant is the use of integrated biosensors as indicating electrodes, where an enzyme is immobilized on, or in close proximity of, the surface of indicating electrode. It can be for instance the covalent immobilization of alkaline phosphatase at the surface of the carboxylate PVC-based pH sensitive ISE, which was then used in an FIA system as an apoenzyme electrode for Zn(II), employing L-cysteine as the most efficient chelator.…”

Section: Electrochemical Detectionsmentioning

confidence: 99%

Recent advances in flow injection analysis

Trojanowicz

Kołacińska

2016

Analyst

168

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A dynamic development of methodologies of analytical flow injection measurements during four decades since their invention has reinforced the solid position of flow analysis in the arsenal of techniques and instrumentation of contemporary chemical analysis. With the number of published scientific papers exceeding 20,000, and advanced instrumentation available for environmental, food, and pharmaceutical analysis, flow analysis is well established as an extremely vital field of modern flow chemistry, which is developed simultaneously with methods of chemical synthesis carried out under flow conditions. This review work is based on almost 300 original papers published mostly in the last decade, with special emphasis put on presenting novel achievements from the most recent 2-3 years in order to indicate current development trends of this methodology. Besides the evolution of the design of whole measuring systems, and including especially new applications of various detections methods, several aspects of implications of progress in nanotechnology, and miniaturization of measuring systems for application in different field of modern chemical analysis are also discussed.

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“…The selectivity can be tuned by varying the structure, and thereby also the ion‐binding properties of the ionophore . So far, acetate‐selective ionophores have been based on porphyrin macromolecules , phenylhydrazone‐based hydrogen bonding molecules , and metal centred Zr(IV)‐porphyrins . These ionophores were used in conventional ISEs with an internal electrolyte solution and should also be applicable to SC‐ISEs because the selectivity of SC‐ISEs is generally determined by the ion‐selective membrane and not by the solid contact .…”

Section: Introductionmentioning

confidence: 99%

Solid‐contact Acetate‐selective Electrode Based on a 1,3‐bis(carbazolyl)urea‐ionophore

et al. 2019

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The construction and study of solid‐contact acetate‐selective electrodes is described using a 1,3‐bis(carbazolyl)urea derivative as a neutral hydrogen‐bonding ionophore and poly(3,4‐ethylenedioxythiophene) as the solid contact. It was shown recently that this ionophore binds acetate (logKass=4.98) that is used as primary ion in this study. The electrodes show linearity over the activity range of 10−4.50–10−1.10 with a sub‐Nernstian slope of −51.3 mV per decade and a detection limit of 10−5.00. The anion‐selectivity pattern of these electrodes deviates markedly from the Hofmeister pattern. When adding ionophore to the membrane the logarithm of the selectivity coefficient (logK) for SCN− decreased from 6.5 to 1.2, logK for I− decreased from 5.7 to 0.9, logK for NO3− decreased from 4.3 to 0.6 and logK for Br− decreased from 3.3 to 0.1. The selectivity coefficients of hydrophilic anions such as Cl−, F−, HPO42−, and SO42− are significantly lower than in case of the ionophore‐free membrane. It was discovered that the constructed electrodes are also relatively selective to bicarbonate. This work is an important step towards the further development of solid‐contact anion‐selective electrodes.

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Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system

Cited by 15 publications

References 35 publications

Potentiometric Carboxylate Sensors Based on Carbazole-Derived Acyclic and Macrocyclic Ionophores

Potentiometric Carboxylate Sensors Based on Carbazole-Derived Acyclic and Macrocyclic Ionophores

Recent advances in flow injection analysis

Solid‐contact Acetate‐selective Electrode Based on a 1,3‐bis(carbazolyl)urea‐ionophore

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