Bioactivity of polyurethane-based scaffolds coated with Bioglass®

Abstract

Polyurethane (PUR) and polyurethane/poly(d, l-lactide) acid (PUR/PDLLA) based scaffolds coated with Bioglass particles for application in bone tissue engineering were fabricated. The slurry-dipping method was used for coating preparation. The homogeneous structure of the Bioglass coatings on the surface of the PUR and PUR/PDLLA foams indicated a good adhesion of the bioactive glass particles to polyurethane without any additional surface treatment. In vitro studies in simulated body fluid (SBF) were performed to study the influence of Bioglass coating on biodegrability and bioactivity of PUR-based scaffolds. The surface of Bioglass-coated samples was covered by a layer of carbonate-containing apatite after 7 days of immersion in SBF, while in uncoated polymer samples apatite crystals were not detected even after 21 days of immersion in SBF. The apatite layer was characterized by scanning electron microscopy (SEM), EDS analysis and attenuated total reflectance-Fourier transform infrared spectrometry (FTIR-ATR). Weight loss measurements showed that the in vitro degradation rate of the composite scaffolds in SBF was higher in comparison to uncoated polyurethane samples. PUR and PUR/PDLLA foams with Bioglass coating have potential to be used as bioactive, biodegradable scaffolds in bone tissue engineering.

Glass-based coatings on biomedical implants: a state-of-the-art review

“…Bioglass -coated polyurethane and polyurethane/PDLLA foams were also prepared by dipping cycles to improve the bioactivity of the polymeric substrate [20]. A similar approach was reported by Baino et al [21] who coated polyurethane foams with a layer of CEL2 glass particles (Fig.…”

Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

“…28,29 The bands in the range 1040-1220 cm −1 are related to vibration of C-O and C-O-C groups. 7,28,29 Disappearance of the isocyanate group's peak (2270 cm −1 ) revealed the fact that HMDI reacted well, and polymerization has been completed throughout the synthesis. Various modes of -CH 2 vibrations are manifested in the range 1260-1465 cm −1 .…”

“…6 One solution is blending the polyurethanes with bioactive ceramic particles such as tricalcium phosphate or hydroxyapatite (HA). [6][7][8][9][10] A combination of ceramic and polyurethane could improve bioactivity and enhance the mechanical properties of porous scaffolds. that of human hard tissues.…”

Electrospun Nanocomposite Materials, A Novel Synergy of Polyurethane and Bovine Derived Hydroxyapatite

“…The peaks between 1000-1200 cm -1 region denote the (PO4) -3 group which is characteristic for HA. The bands in the 570 and 1000 cm -1 specify the P-O bonds of PU and 630 cm -1 indicates the O-H, 600 and 560 indicates the P-O bonds of HA [16][17][18][19]. …”