Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension

Zhang, Yu; Xiao, Jun; Xiao, Chen; Ruan, Yiwen; Yang, Chen; Zheng, Xiaoyuan; Wang, Qiang

doi:10.1186/s13020-022-00568-w

Cited by 4 publications

(2 citation statements)

References 155 publications

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“…Resveratrol also inhibited the expression of HIF 1A by suppressing the intracellular signaling pathways MAP/ERK1 and P13K. The suppression of VEGF, a downstream gene of HIF 1A, verified those results 25,40,41 .…”

Section: Novel Treatment: Resveratrolsupporting

confidence: 73%

Exposure to the Interior Environment of Water-Damaged Buildings Can Activate Hif 1a, Induce Proliferative Physiology and Impair Mitochondrial Metabolism: Implications for Hypoxic Pulmonary Hypertension in Chronic Inflammatory Response Syndrome

Shoemaker

2024

MRAJ

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Hypoxia inducible factor 1A (HIF 1A) is an oxygen sensing nuclear transcription factor that regulates oxygen homeostasis in many illnesses ranging from, but not limited to cancer, heart failure, premature infants to viral infections. We report here measurement of HIF 1A using transcriptomics as a biomarker in Chronic Inflammatory Response Syndrome (CIRS), a systemic inflammatory and metabolic illness characterized by a multisystem, multi-symptom illness acquired following exposure to the interior environment of water-damaged buildings (WDB). Pulmonary artery hypertension (PAH) is well established but treatment is problematic, depending on its physiologic basis. Reduction of HIF 1A by other modalities does not approach the reduction of HIF 1A reported here. As shown by current literature, reduction of HIF 1A is crucial in PAH therapy. The additional problem of proliferative physiology in CIRS and PAH suggests a commonality of pathogenesis, with reduction of HIF 1A providing a salutary response. By first reviewing the diverse pathophysiology of PAH, we present data that provide a basis for the demonstrated efficacy of our treatment protocol which was used sequentially in CIRS patients to reduce HIF 1A and to improve molecular hypometabolism, suggesting a basis for a novel approach to treatment of PAH.

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Section: Novel Treatment: Resveratrolsupporting

confidence: 73%

Exposure to the Interior Environment of Water-Damaged Buildings Can Activate Hif 1a, Induce Proliferative Physiology and Impair Mitochondrial Metabolism: Implications for Hypoxic Pulmonary Hypertension in Chronic Inflammatory Response Syndrome

Shoemaker

2024

MRAJ

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“…In recent years, several studies have shown that natural products can simultaneously intervene in multiple parts of the disease because of multitargets and multipathways. They have significant advantages in the treatment of complex diseases such as PH [ 28 ]. Therefore, in the present review, we reviewed the most popular natural products for treating PH and classified the mechanisms involved in these natural products.…”

Section: Pathological Mechanisms Of Phmentioning

confidence: 99%

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Zeng

Wang

Cui

et al. 2023

CIMB

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Pulmonary hypertension (PH) is a lethal disease due to the remodeling of pulmonary vessels. Its pathophysiological characteristics include increased pulmonary arterial pressure and pulmonary vascular resistance, leading to right heart failure and death. The pathological mechanism of PH is complex and includes inflammation, oxidative stress, vasoconstriction/diastolic imbalance, genetic factors, and ion channel abnormalities. Currently, many clinical drugs for the treatment of PH mainly play their role by relaxing pulmonary arteries, and the treatment effect is limited. Recent studies have shown that various natural products have unique therapeutic advantages for PH with complex pathological mechanisms owing to their multitarget characteristics and low toxicity. This review summarizes the main natural products and their pharmacological mechanisms in PH treatment to provide a useful reference for future research and development of new anti-PH drugs and their mechanisms.

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Therapeutic effects and mechanism of action of lavender essential oil on atopic dermatitis by modulating the STAT3/RORγt pathway

Duan,

Li,

Wang

et al. 2024

Arabian Journal of Chemistry

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Bioactivities and mechanisms of natural medicines in the management of pulmonary arterial hypertension

Cited by 4 publications

References 155 publications

Exposure to the Interior Environment of Water-Damaged Buildings Can Activate Hif 1a, Induce Proliferative Physiology and Impair Mitochondrial Metabolism: Implications for Hypoxic Pulmonary Hypertension in Chronic Inflammatory Response Syndrome

Exposure to the Interior Environment of Water-Damaged Buildings Can Activate Hif 1a, Induce Proliferative Physiology and Impair Mitochondrial Metabolism: Implications for Hypoxic Pulmonary Hypertension in Chronic Inflammatory Response Syndrome

Natural Products for the Treatment of Pulmonary Hypertension: Mechanism, Progress, and Future Opportunities

Therapeutic effects and mechanism of action of lavender essential oil on atopic dermatitis by modulating the STAT3/RORγt pathway

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