Bioactive traditional plant <i>Cinnamomum zeylanicum</i> successfully combat against nephrotoxic effects of aminoglycosides

Abstract

Cinnamomum zeylanicum is traditionally used for the treatment of bladder and kidney problems; believed to have kidney tonic effects. The prime objective of the current study was to explore the nephroprotective effects of the plant due to its strong antioxidant properties, to provide experimental facts for their traditional use. Daily dose of 200 mg/kg of plant extract was employed alone and in combination with gentamicin for a period of twenty one days in rabbits. Biochemical kidney functioning parameters were assessed thrice throughout study period. Histopathological examination of the kidneys was performed on the last day of experimental period. Present study showed that C. zeylanicum significantly attenuated renal functional and histological changes associated with gentamicin as assessed by urea, creatinine, uric acid, electrolytes, urinary protein, and histopathological examination. The plant extract successfully proved to have strong nephroprotective properties, especially against aminoglycosides induced nephrotoxicities. Article Info

The Hypoglycemic and Antioxidant Activity of Cress Seed and Cinnamon on Streptozotocin Induced Diabetes in Male Rats

“…The histological studies showed altered pathological changes in the tissues of kidney and pancreas as a result of diabetes in the positive control group [ 1 , 19 ], whereas treating the diabetic rats with cress seed and cinnamon methanol extract restored the altered tissues nearly to the normal conditions. Ullah et al [ 57 ] stated that cinnamon significantly attenuated aminoglycosides-kidney toxicity by improving the urea, creatinine, uric acid, urinary protein levels, and histopathological alterations of the kidneys. In addition, our result is in agreement with that of Al-Malki and El Rabey [ 19 ].…”

Antihyperlipidemic and renoprotective activities of methanolic extract of <i>Canscora decussata</i> extract in alloxan-induced diabetic rabbits

“…Ipomoea staphylina leaves , Sechium eduleon , Nigella sativaon (Begum et al, 2006), Cinnamomum zeylanicum (Ullah et al, 2013), and grape seed and skin (Hamlaoui et al, 2012) extract shows renoprotective effect.…”

Protective and curative effects of Cestrum nocturnum on rabbit kidney

“…Due to species difference, the values for blood urea nitrogen and creatinine are different in present study but the trend of effect in preventing and improving gentamicin caused toxicity by C. nocturnum is almost identical. A similar study had been carried out by Ullah et al, (2013) who investigated the nephroprotective activity of Cinnamomum zeylanicum. The data of present study is in agreement with the findings of Ullah et al, (2013) in respect of two parameters i.e.…”

“…A similar study had been carried out by Ullah et al, (2013) who investigated the nephroprotective activity of Cinnamomum zeylanicum. The data of present study is in agreement with the findings of Ullah et al, (2013) in respect of two parameters i.e. blood urea nitrogen and serum creatinine, though the actual values of these parameters differ from our data.…”